Title : KRASQ61H Preferentially Signals through MAPK in a RAF Dimer-Dependent Manner in Non-Small Cell Lung Cancer.

Pub. Date : 2020 Sep 1

PMID : 32605999






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 X-ray crystallography of KRASQ61H:GTP revealed that a hyperdynamic switch 2 allows for a more stable interaction with switch 1, suggesting that enhanced RAF activity arises from a combination of absent intrinsic GTP hydrolysis activity and increased affinity for RAF. Guanosine Triphosphate zinc fingers and homeoboxes 2 Homo sapiens
2 X-ray crystallography of KRASQ61H:GTP revealed that a hyperdynamic switch 2 allows for a more stable interaction with switch 1, suggesting that enhanced RAF activity arises from a combination of absent intrinsic GTP hydrolysis activity and increased affinity for RAF. Guanosine Triphosphate zinc fingers and homeoboxes 2 Homo sapiens
3 X-ray crystallography of KRASQ61H:GTP revealed that a hyperdynamic switch 2 allows for a more stable interaction with switch 1, suggesting that enhanced RAF activity arises from a combination of absent intrinsic GTP hydrolysis activity and increased affinity for RAF. Guanosine Triphosphate zinc fingers and homeoboxes 2 Homo sapiens