Title : An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ.

Pub. Date : 1997 Jan

PMID : 8972184






2 Functional Relationships(s)
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1 The impaired ability of EGF to activate the Raf zinc finger variants in situ is attributable, at least in part, to a major decrement in their binding to Ras-GTP; both Raf zinc finger variants exhibit decreased association with Ras (V12) in situ upon coexpression in COS cells, as well as diminished binding in vitro to immobilized, processed COS recombinant Ras(V12)-GTP. Guanosine Triphosphate zinc fingers and homeoboxes 2 Homo sapiens
2 The impaired ability of EGF to activate the Raf zinc finger variants in situ is attributable, at least in part, to a major decrement in their binding to Ras-GTP; both Raf zinc finger variants exhibit decreased association with Ras (V12) in situ upon coexpression in COS cells, as well as diminished binding in vitro to immobilized, processed COS recombinant Ras(V12)-GTP. Guanosine Triphosphate zinc fingers and homeoboxes 2 Homo sapiens