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33660517 | Dietary Geranylgeranyl Pyrophosphate Counteracts the Benefits of Statin Therapy in Experimental Pulmonary Hypertension. | 2021 May 4 |
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32256770 | Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate. | 2020 Apr |
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33597925 | Simvastatin and ROCK Inhibitor Y-27632 Inhibit Myofibroblast Differentiation of Graves' Ophthalmopathy-Derived Orbital Fibroblasts via RhoA-Mediated ERK and p38 Signaling Pathways. | 2020 |
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29319354 | Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension. | 2018 |
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24158494 | The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway. | 2014 May 15 |
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24582560 | HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation. | 2014 Mar 28 |
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22451024 | Inhibitory effects of simvastatin on migration and invasion of rheumatoid fibroblast-like synoviocytes by preventing geranylgeranylation of RhoA. | 2013 Feb |
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22396212 | Prenylation of Rho G-proteins: a novel mechanism regulating gene expression and protein stability in human trabecular meshwork cells. | 2012 Aug |
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20480384 | Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration. | 2011 Oct |
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21052011 | Simvastatin reduces lipoprotein-associated phospholipase A2 in lipopolysaccharide-stimulated human monocyte-derived macrophages through inhibition of the mevalonate-geranylgeranyl pyrophosphate-RhoA-p38 mitogen-activated protein kinase pathway. | 2011 Feb |
2 |
| 11 |
21212187 | Geranylgeranylation facilitates proteasomal degradation of rho G-proteins in human trabecular meshwork cells. | 2011 Mar 25 |
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| 12 |
21844074 | Donor simvastatin treatment abolishes rat cardiac allograft ischemia/reperfusion injury and chronic rejection through microvascular protection. | 2011 Sep 6 |
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21907187 | Lovastatin inhibits proliferation of anaplastic thyroid cancer cells through up-regulation of p27 by interfering with the Rho/ROCK-mediated pathway. | 2011 Dec 1 |
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| 14 |
19683239 | Down-regulation of RhoA is involved in the cytotoxic action of lipophilic statins in HepG2 cells. | 2010 Jan |
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20578043 | Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells. | 2010 Nov 1 |
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| 16 |
19151402 | Increased RhoA and RhoB protein accumulation in cultured human trabecular meshwork cells by lovastatin. | 2009 Jun |
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| 17 |
18469500 | Effects of atorvastatin and pravastatin on signal transduction related to glucose uptake in 3T3L1 adipocytes. | 2008 May |
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| 18 |
17499483 | Elevated small GTPase activation influences the cell proliferation signaling control in Niemann-Pick type C fibroblasts. | 2007 Jul |
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| 19 |
16858009 | Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin. | 2006 Dec |
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| 20 |
16873994 | Inhibitory effect of statins on renal epithelial-to-mesenchymal transition. | 2006 |
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| 21 |
17237547 | Human umbilical vein endothelial cells and human dermal microvascular endothelial cells offer new insights into the relationship between lipid metabolism and angiogenesis. | 2006 |
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15640525 | Thrombin-induced rapid geranylgeranylation of RhoA as an essential process for RhoA activation in endothelial cells. | 2005 Mar 18 |
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| 23 |
15817453 | Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux. | 2005 Jun 10 |
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| 24 |
11334884 | Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: contribution to its anti-angiogenic effect. | 2001 Apr 27 |
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11470741 | Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study. | 2001 Aug |
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