PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33660517-12 2021 In humans fed with a high GGPP diet, blood GGPP levels were increased, and this abolished statin-lowering effects on plasma GGPP and hypoxia-enhanced RhoA activity of blood monocytes that were both also rescued by garlic extracts. geranylgeranyl pyrophosphate 26-30 ras homolog family member A Homo sapiens 150-154 24158494-10 2014 We propose that reduced RhoA activation plays a dominant role in suppression of malignancy by KLK5, since geranylgeranyl pyrophosphate restored active RhoA in KLK5-reverted cells resulting in increased malignancy. geranylgeranyl pyrophosphate 106-134 ras homolog family member A Homo sapiens 24-28 33597925-4 2020 The inhibitory effect of simvastatin on TGF-beta-induced RhoA, ROCK1, and alpha-SMA expression could be reversed by geranylgeranyl pyrophosphate, an intermediate in the biosynthesis of cholesterol. geranylgeranyl pyrophosphate 116-144 ras homolog family member A Homo sapiens 57-61 29319354-12 2018 The MCTP + simvastatin + mevalonate group, MCTP + simvastatin+ FPP group, and MCTP + simvastatin + FPP + GGPP group showed increased mRNA levels of RhoA and ROCK1, as well as increased protein levels of RhoA, compared to the MCTP + simvastatin group. geranylgeranyl pyrophosphate 105-109 ras homolog family member A Homo sapiens 148-152 29319354-12 2018 The MCTP + simvastatin + mevalonate group, MCTP + simvastatin+ FPP group, and MCTP + simvastatin + FPP + GGPP group showed increased mRNA levels of RhoA and ROCK1, as well as increased protein levels of RhoA, compared to the MCTP + simvastatin group. geranylgeranyl pyrophosphate 105-109 ras homolog family member A Homo sapiens 203-207 29319354-15 2018 Simvastatin decreased RhoA/ROCK1 overexpression by inhibition of mevalonate, FPP, and GGPP synthesis. geranylgeranyl pyrophosphate 86-90 ras homolog family member A Homo sapiens 22-26 32256770-15 2020 FPP or GGPP reversed MVK interference-induced decrease in geranylgeranylation levels of lamin A, HRAS, KRAS, NRAS, Rho E, Rho B, Rho A, RAC1 and cdc42. geranylgeranyl pyrophosphate 7-11 ras homolog family member A Homo sapiens 129-134 24158494-10 2014 We propose that reduced RhoA activation plays a dominant role in suppression of malignancy by KLK5, since geranylgeranyl pyrophosphate restored active RhoA in KLK5-reverted cells resulting in increased malignancy. geranylgeranyl pyrophosphate 106-134 ras homolog family member A Homo sapiens 151-155 22451024-7 2013 Furthermore, mevalonate or GGPP treatment reversed the inhibitory effect of simvastatin not only on migration and invasion in vitro but also on RhoA activation, and inhibition of RhoA by specific siRNA transfection reduced migration, adhesion and invasion of RA FLS. geranylgeranyl pyrophosphate 27-31 ras homolog family member A Homo sapiens 144-148 24582560-12 2014 Administration of mevalonate and GGPP reversed the inhibitory effect of simvastatin on CCL17-provoked RhoA activation in colon cancer cells. geranylgeranyl pyrophosphate 33-37 ras homolog family member A Homo sapiens 102-106 22451024-7 2013 Furthermore, mevalonate or GGPP treatment reversed the inhibitory effect of simvastatin not only on migration and invasion in vitro but also on RhoA activation, and inhibition of RhoA by specific siRNA transfection reduced migration, adhesion and invasion of RA FLS. geranylgeranyl pyrophosphate 27-31 ras homolog family member A Homo sapiens 179-183 20480384-10 2011 Geranylgeranyl diphosphate addition prevented the effects of digeranyl bisphosphonate on migration, RhoA localization, and GTP binding to RhoA in MDA-MB-231 cells. geranylgeranyl pyrophosphate 0-26 ras homolog family member A Homo sapiens 100-104 21907187-7 2011 The lovastatin-induced growth inhibition and translocation of RhoA and Rac1 in ARO cells were completely prevented by mevalonate and partially by geranylgeranyl pyrophosphate. geranylgeranyl pyrophosphate 146-174 ras homolog family member A Homo sapiens 62-66 22396212-6 2012 Supplementation with geranylgeranyl pyrophosphate (GGPP) prevented, while inhibition of geranylgeranyl transferase-I mimicked, the effects of lovastatin on RhoA and RhoB protein content. geranylgeranyl pyrophosphate 21-49 ras homolog family member A Homo sapiens 156-160 22396212-6 2012 Supplementation with geranylgeranyl pyrophosphate (GGPP) prevented, while inhibition of geranylgeranyl transferase-I mimicked, the effects of lovastatin on RhoA and RhoB protein content. geranylgeranyl pyrophosphate 51-55 ras homolog family member A Homo sapiens 156-160 20480384-10 2011 Geranylgeranyl diphosphate addition prevented the effects of digeranyl bisphosphonate on migration, RhoA localization, and GTP binding to RhoA in MDA-MB-231 cells. geranylgeranyl pyrophosphate 0-26 ras homolog family member A Homo sapiens 138-142 21212187-7 2011 Addition of geranylgeranyl pyrophosphate to the culture medium restored actin stress fiber organization while selectively facilitating the subcellular redistribution of accumulated Rho proteins from cytosol to membrane and increasing RhoA activation. geranylgeranyl pyrophosphate 12-40 ras homolog family member A Homo sapiens 234-238 21844074-6 2011 The beneficial effects of simvastatin on vascular stability and the no-reflow phenomenon were abolished by concomitant nitric oxide synthase inhibition with N-nitro-l-arginine methyl ester and RhoA activation by geranylgeranyl pyrophosphate supplementation, respectively. geranylgeranyl pyrophosphate 212-240 ras homolog family member A Homo sapiens 193-197 21052011-0 2011 Simvastatin reduces lipoprotein-associated phospholipase A2 in lipopolysaccharide-stimulated human monocyte-derived macrophages through inhibition of the mevalonate-geranylgeranyl pyrophosphate-RhoA-p38 mitogen-activated protein kinase pathway. geranylgeranyl pyrophosphate 165-193 ras homolog family member A Homo sapiens 194-198 21052011-7 2011 In addition, treatment with simvastatin blocked LPS-induced activation of RhoA, which could be abolished by treatment with GGPP. geranylgeranyl pyrophosphate 123-127 ras homolog family member A Homo sapiens 74-78 18469500-6 2008 The amounts of Rab4 and RhoA that required lipid modification with farnesyl or geranylgeranyl pyrophosphate, in the membrane fraction were decreased by atorvastatin. geranylgeranyl pyrophosphate 79-107 ras homolog family member A Homo sapiens 24-28 20578043-5 2010 However, the depletion of geranylgeranyl-pp under normal cholesterol homeostasis conditions enhanced the phenotypic commitment and differentiation of LOV-treated OPCs ascribed to inhibition of RhoA-Rho kinase. geranylgeranyl pyrophosphate 26-43 ras homolog family member A Homo sapiens 193-197 19151402-8 2009 Supplementation with mevalonate or geranylgeranyl pyrophosphate prevented, whereas inhibition of geranylgeranyl transferase mimicked, the effects of lovastatin on RhoA and RhoB accumulation. geranylgeranyl pyrophosphate 35-63 ras homolog family member A Homo sapiens 163-167 19683239-11 2010 CONCLUSIONS: RhoA inactivation and to a lesser extent Rho-kinase inhibition after depletion of GGPP is implicated in the etiology of mitochondrial membrane depolarization and subsequent caspase-dependent cell death induced by the lipophilic statin in HepG2 cells. geranylgeranyl pyrophosphate 95-99 ras homolog family member A Homo sapiens 13-17 11470741-7 2001 The importance of RhoA inactivation in both these inhibitory effects was proved by their reversion by GGPP but not by FPP. geranylgeranyl pyrophosphate 102-106 ras homolog family member A Homo sapiens 18-22 17499483-8 2007 However, NPC sensitivity to statin treatment is reversed by addition of the isoprenoid geranylgeranyl pyrophosphate (GGPP), a modifier of RhoA. geranylgeranyl pyrophosphate 87-115 ras homolog family member A Homo sapiens 138-142 17499483-8 2007 However, NPC sensitivity to statin treatment is reversed by addition of the isoprenoid geranylgeranyl pyrophosphate (GGPP), a modifier of RhoA. geranylgeranyl pyrophosphate 117-121 ras homolog family member A Homo sapiens 138-142 16858009-9 2006 Moreover, the inhibitory effect of simvastatin on FBS-induced RhoA activation was also antagonized by geranylgeranylpyrophosphate, but not by farnesylpyrophosphate. geranylgeranyl pyrophosphate 102-129 ras homolog family member A Homo sapiens 62-66 15817453-2 2005 Oxysterols through liver X receptor (LXR) activation regulate cholesterol efflux, whereas the non-sterol mevalonate metabolite, geranylgeranyl pyrophosphate (GGPP), was recently demonstrated to inhibit ABCA1 expression directly, through antagonism of LXR and indirectly through enhanced RhoA geranylgeranylation. geranylgeranyl pyrophosphate 128-156 ras homolog family member A Homo sapiens 287-291 15817453-2 2005 Oxysterols through liver X receptor (LXR) activation regulate cholesterol efflux, whereas the non-sterol mevalonate metabolite, geranylgeranyl pyrophosphate (GGPP), was recently demonstrated to inhibit ABCA1 expression directly, through antagonism of LXR and indirectly through enhanced RhoA geranylgeranylation. geranylgeranyl pyrophosphate 158-162 ras homolog family member A Homo sapiens 287-291 15640525-8 2005 Importantly, the addition of geranylgeranylpyrophosphate to ECs pretreated with atorvastatin quickly reversed the atorvastatin inhibition of thrombin stimulation of RhoA. geranylgeranyl pyrophosphate 29-56 ras homolog family member A Homo sapiens 165-169 16873994-3 2006 We hypothesized that statins could act by inhibiting the synthesis of the isoprenoids, such as geranylgeranyl pyrophosphate, which is essential for membrane attachment and biological activity of RhoGTPases, RhoA and Rac1. geranylgeranyl pyrophosphate 95-123 ras homolog family member A Homo sapiens 207-211 16873994-7 2006 The decreased levels of activated RhoA and Rac1 in both the cytoplasmic and membrane fractions of the cells were reversed by geranylgeranyl pyrophosphate and mevalonate, and thus attributable to the inhibition of isoprenylation of RhoGTPases by statins. geranylgeranyl pyrophosphate 125-153 ras homolog family member A Homo sapiens 34-38 17237547-6 2006 Geranylgeranyl-pyrophosphate (GGPP), a product of the cholesterol metabolic pathway that serves as a substrate for the posttranslational lipidation of RhoA, was required for membrane localization, but not farnesylpyrophosphate (FPP), the substrate for the lipidation of Ras. geranylgeranyl pyrophosphate 0-28 ras homolog family member A Homo sapiens 151-155 17237547-6 2006 Geranylgeranyl-pyrophosphate (GGPP), a product of the cholesterol metabolic pathway that serves as a substrate for the posttranslational lipidation of RhoA, was required for membrane localization, but not farnesylpyrophosphate (FPP), the substrate for the lipidation of Ras. geranylgeranyl pyrophosphate 30-34 ras homolog family member A Homo sapiens 151-155 11334884-2 2001 It could act by inhibiting the synthesis of isoprenoids (farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP)), which are respectively essential for membrane attachment and biological activity of GTPases Ras and RhoA. geranylgeranyl pyrophosphate 89-116 ras homolog family member A Homo sapiens 226-230 11334884-2 2001 It could act by inhibiting the synthesis of isoprenoids (farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP)), which are respectively essential for membrane attachment and biological activity of GTPases Ras and RhoA. geranylgeranyl pyrophosphate 118-122 ras homolog family member A Homo sapiens 226-230