Title : Down-regulation of RhoA is involved in the cytotoxic action of lipophilic statins in HepG2 cells.

Pub. Date : 2010 Jan

PMID : 19683239






1 Functional Relationships(s)
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1 CONCLUSIONS: RhoA inactivation and to a lesser extent Rho-kinase inhibition after depletion of GGPP is implicated in the etiology of mitochondrial membrane depolarization and subsequent caspase-dependent cell death induced by the lipophilic statin in HepG2 cells. geranylgeranyl pyrophosphate ras homolog family member A Homo sapiens