Title : The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway.

Pub. Date : 2014 May 15

PMID : 24158494






2 Functional Relationships(s)
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1 We propose that reduced RhoA activation plays a dominant role in suppression of malignancy by KLK5, since geranylgeranyl pyrophosphate restored active RhoA in KLK5-reverted cells resulting in increased malignancy. geranylgeranyl pyrophosphate ras homolog family member A Homo sapiens
2 We propose that reduced RhoA activation plays a dominant role in suppression of malignancy by KLK5, since geranylgeranyl pyrophosphate restored active RhoA in KLK5-reverted cells resulting in increased malignancy. geranylgeranyl pyrophosphate ras homolog family member A Homo sapiens