Paclitaxel

tumor protein p53 ; Homo sapiens







240 Article(s)
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51 25310526 +TIP EB1 downregulates paclitaxel‑induced proliferation inhibition and apoptosis in breast cancer cells through inhibition of paclitaxel binding on microtubules. 2015 Jan 2
52 25351378 Biological characteristics of Taxol‑resistant ovarian cancer cells and reversal of Taxol resistance by adenovirus expressing p53. 2015 Feb 1
53 25499080 Mutations of p53 and KRAS activate NF-κB to promote chemoresistance and tumorigenesis via dysregulation of cell cycle and suppression of apoptosis in lung cancer cells. 2015 Feb 28 1
54 25596561 Mechanism of synergy of BH3 mimetics and paclitaxel in chronic myeloid leukemia cells: Mcl-1 inhibition. 2015 Apr 5 1
55 25633416 3,3'-Diindolylmethane potentiates paclitaxel-induced antitumor effects on gastric cancer cells through the Akt/FOXM1 signaling cascade. 2015 Apr 1
56 25647149 Increased chemoresistance to paclitaxel in the MCF10AT series of human breast epithelial cancer cells. 2015 Apr 2
57 25780454 Curcumin improves the paclitaxel-induced apoptosis of HPV-positive human cervical cancer cells via the NF-κB-p53-caspase-3 pathway. 2015 Apr 5
58 26146988 CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis. 2015 3
59 26177745 Concentration-dependent differential effects of an epothilone analog on cell cycle and p53 signaling. 2015 Sep 1
60 26309162 Enhanced transfection efficiency and targeted delivery of self-assembling h-R3-dendriplexes in EGFR-overexpressing tumor cells. 2015 Sep 22 1
61 24189097 Supramolecular self-assembly forming a multifunctional synergistic system for targeted co-delivery of gene and drug. 2014 Jan 3
62 24565839 p53 down-regulates SETDB1 gene expression during paclitaxel induced-cell death. 2014 Mar 28 3
63 24712391 Combinational delivery of hydrophobic and hydrophilic anticancer drugs in single nanoemulsions to treat MDR in cancer. 2014 Aug 4 1
64 24787013 Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases. 2014 May 1 1
65 25411964 Overexpression of forkhead box protein M1 (FOXM1) in ovarian cancer correlates with poor patient survival and contributes to paclitaxel resistance. 2014 1
66 25688502 Evaluation of chemoradiotherapy with carbon ions and the influence of p53 mutational status in the colorectal carcinoma cell line HCT 116. 2014 Nov-Dec 1
67 23161364 p53 acetylation enhances Taxol-induced apoptosis in human cancer cells. 2013 Jan 18
68 23534290 Biochemical effects of combined action of gamma-irradiation and paclitaxel on anaplastic thyroid cancer cells. 2013 Jan-Feb 1
69 23735541 Apoptosis induced by paclitaxel via Bcl-2, Bax and caspases 3 and 9 activation in NB4 human leukaemia cells is not modulated by ERK inhibition. 2013 Nov 1
70 24141649 Establishment and characterization of seven human breast cancer cell lines including two triple-negative cell lines. 2013 Dec 1
71 24381593 Strategies for Molecularly Enhanced Chemotherapy to Achieve Synthetic Lethality in Endometrial Tumors with Mutant p53. 2013 4
72 24601052 In vitro chemosensitivity assay of ascites in epithelial ovarian cancer. 2013 1
73 22489661 Radiation/paclitaxel treatment of p53-abnormal non-small cell lung cancer xenograft tumor and associated mechanism. 2012 May 1
74 22493354 Radiosensitization of p53-deficient lung cancer cells by pre-treatment with cytostatic compounds. 2012 Apr 1
75 22534478 Prognostic value of expression of Kit67, p53, TopoIIa and GSTP1 for curatively resected advanced gastric cancer patients receiving adjuvant paclitaxel plus capecitabine chemotherapy. 2012 Jul-Aug 3
76 22549660 Fluoxetine synergys with anticancer drugs to overcome multidrug resistance in breast cancer cells. 2012 Oct 1
77 22765290 Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents. 2012 Oct 1
78 22885806 Apoptotic-like death occurs through a caspase-independent route in colon carcinoma cells undergoing mitotic catastrophe. 2012 Dec 29 3
79 23023313 Taxol-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. 2012 Dec 2
80 21109480 p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma. 2011 Jan 1
81 21354697 miR-203 reverses chemoresistance in p53-mutated colon cancer cells through downregulation of Akt2 expression. 2011 May 1 1
82 21482024 A FGFR2 inhibitor, Ki23057, enhances the chemosensitivity of drug-resistant gastric cancer cells. 2011 Aug 1 1
83 21514041 Gene expression signature of TP53 but not its mutation status predicts response to sequential paclitaxel and 5-FU/epirubicin/cyclophosphamide in human breast cancer. 2011 Aug 28 2
84 21556366 Predictive and prognostic impact of TP53 mutations and MDM2 promoter genotype in primary breast cancer patients treated with epirubicin or paclitaxel. 2011 Apr 27 3
85 21594648 Overexpression of miR-22 reverses paclitaxel-induced chemoresistance through activation of PTEN signaling in p53-mutated colon cancer cells. 2011 Nov 3
86 21693655 p53 Expression in node-positive breast cancer patients: results from the Cancer and Leukemia Group B 9344 Trial (159905). 2011 Aug 1 2
87 21926165 iASPP and chemoresistance in ovarian cancers: effects on paclitaxel-mediated mitotic catastrophe. 2011 Nov 1 1
88 22077725 Effects of estrogen metabolite 2-methoxyestradiol on tumor suppressor protein p53 and proliferation of breast cancer cells. 2011 Dec 2
89 22194993 Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo. 2011 3
90 19918798 Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt. 2010 Feb 4
91 20178585 Protection of p53 wild type cells from taxol by nutlin-3 in the combined lung cancer treatment. 2010 Feb 23 1
92 20624405 Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells. 2010 Sep 11 2
93 20661829 Protection of p53 wild type cells from taxol by genistein in the combined treatment of lung cancer. 2010 4
94 20878066 Amifostine enhancement of the anti-cancer effects of paclitaxel in endometrial cancer is TP53-dependent. 2010 Nov 6
95 20944137 Increasing p53 protein sensitizes non-small cell lung cancer to paclitaxel and cisplatin in vitro. 2010 Sep 3
96 18758183 P27 and P53 gene polymorphisms and restenosis following coronary implantation of drug-eluting stents. 2009 1
97 19052714 TP53 codon 72 polymorphism associated with prognosis in patients with advanced gastric cancer treated with paclitaxel and cisplatin. 2009 Jul 2
98 19148534 Anticancer effects on TACC3 by treatment of paclitaxel in HPV-18 positive cervical carcinoma cells. 2009 Feb 1
99 19217709 Role of p53 in the induction of cyclooxygenase-2 by cisplatin or paclitaxel in non-small cell lung cancer cell lines. 2009 Jun 28 4
100 19332559 TTK/hMps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at Thr18. 2009 Jun 1