Pub. Date : 2015 Apr
PMID : 25780454
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin improves the paclitaxel-induced apoptosis of HPV-positive human cervical cancer cells via the NF-kappaB-p53-caspase-3 pathway. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 2 | The expression levels of p53 protein and cleaved caspase-3 were increased significantly in the curcumin plus paclitaxel-treated HeLa and CaSki cells compared with those in the cells treated with paclitaxel alone (P<0.01). | Paclitaxel | tumor protein p53 | Homo sapiens |
| 3 | The expression levels of p53 protein and cleaved caspase-3 were increased significantly in the curcumin plus paclitaxel-treated HeLa and CaSki cells compared with those in the cells treated with paclitaxel alone (P<0.01). | Paclitaxel | tumor protein p53 | Homo sapiens |
| 4 | This suggests that the combined effect of curcumin and paclitaxel was associated with the NF-kappaB-p53-caspase-3 pathway. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 5 | In conclusion, curcumin has the ability to improve the paclitaxel-induced apoptosis of HPV-positive human cervical cancer cell lines via the NF-kappaB-p53-caspase-3 pathway. | Paclitaxel | tumor protein p53 | Homo sapiens |