Metals

tumor protein p53 ; Homo sapiens







47 Article(s)
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1 35487360 Critical target identification and human health risk ranking of metal ions based on mechanism-driven modeling. 2022 Aug 7
2 35513212 Oxidative stress-amplified nanomedicine for intensified ferroptosis-apoptosis combined tumor therapy. 2022 May 6 2
3 33538587 Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53. 2021 Feb 25 1
4 34028595 Sirtuins as molecular targets, mediators, and protective agents in metal-induced toxicity. 2021 Jul 1
5 34163734 Multiplexed and amplified chemiluminescence resonance energy transfer (CRET) detection of genes and microRNAs using dye-loaded hemin/G-quadruplex-modified UiO-66 metal-organic framework nanoparticles. 2021 Feb 8 1
6 34786438 Urea Denaturation, Zinc Binding, and DNA Binding Assays of Mutant p53 DNA-binding Domains and Full-length Proteins. 2021 Oct 20 1
7 32138726 Suitability of MDA, 8-OHdG and wild-type p53 as genotoxic biomarkers in metal (Co, Ni and Cr) exposed dental technicians: a cross-sectional study. 2020 Mar 6 1
8 32976933 Lead and cadmium exposure induces male reproductive dysfunction by modulating the expression profiles of apoptotic and survival signal proteins in tea-garden workers. 2020 Dec 2
9 33317179 Single Cell Detection of the p53 Protein by Mass Cytometry. 2020 Dec 9 1
10 30286548 Integrative analysis of methylome and transcriptome variation of identified cardiac disease-specific genes in human cardiomyocytes after PM2.5 exposure. 2018 Dec 1
11 28754018 Investigating the Influence of Magnesium Ions on p53-DNA Binding Using Atomic Force Microscopy. 2017 Jul 21 2
12 30345409 Chemical-agnostic hazard prediction: statistical inference of in vitro toxicity pathways from proteomics responses to chemical mixtures. 2017 May 1
13 27390612 Transduction of Recombinant M3-p53-R12 Protein Enhances Human Leukemia Cell Apoptosis. 2016 1
14 25563581 microRNA profiling in three main stages during porcine spermatogenesis. 2015 Mar 1
15 25710967 Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore. 2015 May 1
16 26391003 Study of antitumor effect of selected vanadium and molybdenum organometallic complexes in human leukemic T-cells. 2015 Dec 5 2
17 25294809 Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism. 2014 Oct 15 1
18 23201157 A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2. 2013 Feb 1
19 20875833 Role of hepatocyte nuclear factor 4α in controlling copper-responsive transcription. 2011 Jan 1
20 21194611 Toxicity of depleted uranium complexes is independent of p53 activity. 2011 Feb 1
21 21072344 The missing zinc: p53 misfolding and cancer. 2010 Jul 1
22 19346293 Effect of metal ion on the structural stability of tumour suppressor protein p53 DNA-binding domain. 2009 Aug 4
23 19655389 Metallothionein-I+II in neuroprotection. 2009 Jul-Aug 1
24 18547707 Mechanisms of chromium (VI)-induced apoptosis in anterior pituitary cells. 2008 Jul 30 1
25 17477370 P53 mediated regulation of metallothionein transcription in breast cancer cells. 2007 Dec 15 1
26 15711927 Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells. 2005 Jan 1
27 15827887 Expression of apoptosis-related proteins in model of anoxia in vitro. 2005 1
28 15880691 Inhibition of extracellular signal regulated kinase (ERK) leads to apoptosis inducing factor (AIF) mediated apoptosis in epithelial breast cancer cells: the lack of effect of ERK in p53 mediated copper induced apoptosis. 2005 Aug 15 1
29 16007197 Quantitation of p53 nuclear relocation in response to stress using a yeast functional assay: effects of irradiation and modulation by heavy metal ions. 2005 Sep 22 2
30 15001399 Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc. 2004 Mar 15 2
31 11554448 Zinc binding and redox control of p53 structure and function. 2001 Aug 3
32 11697035 Sequence-specific DNA damage induced by carcinogenic danthron and anthraquinone in the presence of Cu(II), cytochrome P450 reductase and NADPH. 2001 Jun 1
33 10942736 The role of hydroxyl radical as a messenger in Cr(VI)-induced p53 activation. 2000 Sep 1
34 10998350 p53 protein oxidation in cultured cells in response to pyrrolidine dithiocarbamate: a novel method for relating the amount of p53 oxidation in vivo to the regulation of p53-responsive genes. 2000 Oct 1 1
35 11077439 Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells. 2000 Nov 2 2
36 22607421 Effects of Oxidation Agents and Metal Ions on Binding of p53 to Supercoiled DNA. 2000 1
37 10604188 Metal ions as regulators of the conformation and function of the tumour suppressor protein p53: implications for carcinogenesis. 1999 Aug 5
38 9315628 Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper. 1997 Oct 1
39 8605209 Site-specific DNA damage induced by NADH in the presence of copper(II): role of active oxygen species. 1996 Apr 9 1
40 8617769 Modification of an N-terminal regulatory domain of T antigen restores p53-T antigen complex formation in the absence of an essential metal ion cofactor. 1996 Mar 1 1
41 7790313 Nuclear accumulation of p53 in normal human fibroblasts is induced by various cellular stresses which evoke the heat shock response, independently of the cell cycle. 1995 May 1
42 7841034 Temperature sensitivity for conformation is an intrinsic property of wild-type p53. 1995 Feb 3
43 7811703 Divalent metal ions induce conformational change in pure, human wild-type p53 tumor suppressor protein. 1994 Dec 14 1
44 8168507 Biochemical characterisation of purified human wild-type p53 overexpressed in insect cells. 1994 Apr 1 1
45 8221671 Sequence-specific interaction of a conformational domain of p53 with DNA. 1993 Nov 15 2
46 8402615 Redox modulation of p53 conformation and sequence-specific DNA binding in vitro. 1993 Oct 1 1
47 8467489 A structural role for metal ions in the "wild-type" conformation of the tumor suppressor protein p53. 1993 Apr 15 3