Title : Urea Denaturation, Zinc Binding, and DNA Binding Assays of Mutant p53 DNA-binding Domains and Full-length Proteins.

Pub. Date : 2021 Oct 20

PMID : 34786438






1 Functional Relationships(s)
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1 This interplay is particularly evident in zinc-binding transcription factors such as the p53 tumor suppressor, whose DNA-binding activity can critically depend on levels of intracellular zinc as well as point mutations that alter either metal binding or folding stability. Metals tumor protein p53 Homo sapiens