Pub. Date : 1993 Apr 15
PMID : 8467489
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A structural role for metal ions in the "wild-type" conformation of the tumor suppressor protein p53. | Metals | tumor protein p53 | Homo sapiens |
| 2 | Here we show that exposure to the metal chelator 1,10-phenanthroline induces wild-type p53 to adopt the mutant conformation and that this process is reversible. | Metals | tumor protein p53 | Homo sapiens |
| 3 | We propose that binding of metal ions, most probably zinc, to conserved cysteinyl residues stabilizes the tertiary structure of wild-type p53. | Metals | tumor protein p53 | Homo sapiens |