| 1 |
23860250 | Design of novel Geldanamycin analogue hsp90 alpha-inhibitor in silico for breast cancer therapy. | 2013 Sep |
1 |
| 2 |
22138446 | Hsp90 inhibitors sensitise human colon cancer cells to topoisomerase I poisons by depletion of key anti-apoptotic and cell cycle checkpoint proteins. | 2012 Feb 1 |
4 |
| 3 |
22433057 | Combined effect of Hsp90 inhibitor geldanamycin and parthenolide via reactive oxygen species-mediated apoptotic process on epithelial ovarian cancer cells. | 2012 Sep |
1 |
| 4 |
22865487 | 18β-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway. | 2012 Nov |
1 |
| 5 |
21663398 | Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation. | 2011 Sep |
1 |
| 6 |
20493187 | Geldanamycin and its analog induce cytotoxicity in cultured human retinal pigment epithelial cells. | 2010 Aug |
1 |
| 7 |
17982489 | Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells. | 2008 Apr 10 |
1 |
| 8 |
18071310 | Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1. | 2008 May 15 |
2 |
| 9 |
18504430 | Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells. | 2008 Sep 18 |
4 |
| 10 |
18630678 | [Effect of HSP90 function inhibited on the telomerase and P53 mutant in breast cancer cells]. | 2008 Mar |
2 |
| 11 |
17268519 | Pharmacologic activation of p53-dependent and p53-independent apoptotic pathways in Hodgkin/Reed-Sternberg cells. | 2007 Apr |
3 |
| 12 |
17293044 | Resistance to geldanamycin-induced apoptosis in differentiated neuroblastoma SH-SY5Y cells. | 2007 Mar 6 |
2 |
| 13 |
17666403 | CHIP chaperones wild type p53 tumor suppressor protein. | 2007 Sep 28 |
1 |
| 14 |
15613472 | Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: implications for cancer therapy. | 2005 Feb 25 |
1 |
| 15 |
15284248 | Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cells. | 2004 Oct 8 |
2 |
| 16 |
15358769 | Hsp90 chaperones wild-type p53 tumor suppressor protein. | 2004 Nov 19 |
2 |
| 17 |
12427754 | Phosphorylation and hsp90 binding mediate heat shock stabilization of p53. | 2003 Jan 17 |
2 |
| 18 |
12810654 | Geldanamycin and its 17-allylamino-17-demethoxy analogue antagonize the action of Cisplatin in human colon adenocarcinoma cells: differential caspase activation as a basis for interaction. | 2003 Jun 15 |
1 |
| 19 |
12843186 | The heat shock protein 90-binding geldanamycin inhibits cancer cell proliferation, down-regulates oncoproteins, and inhibits epidermal growth factor-induced invasion in thyroid cancer cell lines. | 2003 Jul |
3 |
| 20 |
11867746 | NQO1 stabilizes p53 through a distinct pathway. | 2002 Mar 5 |
2 |
| 21 |
10557093 | The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association. | 1999 Oct 28 |
1 |
| 22 |
9488468 | The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent. | 1998 Mar |
4 |
| 23 |
9622079 | Metabolism of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) by murine and human hepatic preparations. | 1998 Jun 1 |
1 |
| 24 |
9137531 | Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity. | 1997 |
4 |
| 25 |
9190897 | Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo. | 1997 Jun 12 |
6 |
| 26 |
9417863 | Geldanamycin prevents nuclear translocation of mutant p53. | 1997 Nov 25 |
5 |
| 27 |
8599864 | Cell-cycle arrest and p53 accumulation induced by geldanamycin in human ovarian tumour cells. | 1996 |
5 |
| 28 |
7675452 | Geldanamycin selectively destabilizes and conformationally alters mutated p53. | 1995 Sep 7 |
2 |