Title : Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1.

Pub. Date : 2008 May 15

PMID : 18071310






2 Functional Relationships(s)
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1 Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1. geldanamycin tumor protein p53 Homo sapiens
2 These results suggest that abrogation of G2 checkpoint by GM may play a central role in sensitizing p53-negative tumor cells to DNA-damaging and decatenation-inhibiting agents. geldanamycin tumor protein p53 Homo sapiens