Title : The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent.

Pub. Date : 1998 Mar

PMID : 9488468






4 Functional Relationships(s)
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1 The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent. geldanamycin tumor protein p53 Homo sapiens
2 To examine the effect of directly disrupting chaperone interactions with mutant p53, we made use of geldanamycin (GA), a selective hsp90-binding agent which has been shown to alter the chaperone associations regulating the function of unliganded steroid receptors. geldanamycin tumor protein p53 Homo sapiens
3 To examine the effect of directly disrupting chaperone interactions with mutant p53, we made use of geldanamycin (GA), a selective hsp90-binding agent which has been shown to alter the chaperone associations regulating the function of unliganded steroid receptors. geldanamycin tumor protein p53 Homo sapiens
4 GA treatment of cells altered heteroprotein complex formation with several different mutant p53 species. geldanamycin tumor protein p53 Homo sapiens