Pub. Date : 1997 Nov 25
PMID : 9417863
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Geldanamycin prevents nuclear translocation of mutant p53. | geldanamycin | tumor protein p53 | Homo sapiens |
| 2 | Treatment of transformed cells with geldanamycin (GA), a small molecule that binds hsp90, causes a rapid destabilization of p53 by 50%. | geldanamycin | tumor protein p53 | Homo sapiens |
| 3 | Treatment of transformed cells with geldanamycin (GA), a small molecule that binds hsp90, causes a rapid destabilization of p53 by 50%. | geldanamycin | tumor protein p53 | Homo sapiens |
| 4 | Although GA appears to dramatically alter the translocating properties of mutant p53 it does not dissociate the p53-hsp90 complex. | geldanamycin | tumor protein p53 | Homo sapiens |
| 5 | We suggest that a second chaperone protein, called p23, which we show also binds p53, may play an important role in these GA-mediated effects. | geldanamycin | tumor protein p53 | Homo sapiens |