Acetylcysteine

tumor protein p53 ; Homo sapiens







68 Article(s)
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1 35065218 Chlorine exposure induces Caspase-3 independent cell death in human lung epithelial cells. 2022 Apr 1
2 35215995 Ergosterol Peroxide Inhibits Porcine Epidemic Diarrhea Virus Infection in Vero Cells by Suppressing ROS Generation and p53 Activation. 2022 Feb 15 1
3 32864863 Curcumin induced apoptosis is mediated through oxidative stress in mutated p53 and wild type p53 colon adenocarcinoma cell lines. 2021 Jan 1
4 33781788 T-17, a spirostanol saponin, inhibits p53-independent proliferation and p53-dependent migration of gastric cancer cells. 2021 Jun 2
5 34447990 Increased H2O2 levels and p53 stabilization lead to mitochondrial dysfunction in XPC-deficient cells. 2021 Nov 12 2
6 34681647 Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma. 2021 Oct 12 1
7 31812668 Mutant p53 induces SIRT3/MnSOD axis to moderate ROS production in melanoma cells. 2020 Jan 15 1
8 31945496 Thiol antioxidants sensitize malabaricone C induced cancer cell death via reprogramming redox sensitive p53 and NF-κB proteins in vitro and in vivo. 2020 Feb 20 1
9 31959867 TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency. 2020 Jan 1
10 31995555 Application of non-invasive low-intensity pulsed electric field with thermal cycling-hyperthermia for synergistically enhanced anticancer effect of chlorogenic acid on PANC-1 cells. 2020 2
11 32905825 4-Aminobiphenyl suppresses homologous recombination repair by a reactive oxygen species-dependent p53/miR-513a-5p/p53 loop. 2020 Nov 4
12 33139577 Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47phox. 2020 Nov 17 1
13 30447351 N-acetylcysteine ameliorates cisplatin-induced renal senescence and renal interstitial fibrosis through sirtuin1 activation and p53 deacetylation. 2019 Jan 3
14 30483736 Attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS. 2019 Feb 1
15 30865562 Stretching magnitude-dependent inactivation of AKT by ROS led to enhanced p53 mitochondrial translocation and myoblast apoptosis. 2019 May 1 2
16 31752383 Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation. 2019 Nov 19 2
17 29392716 N-acetyl-L-cysteine improves mesenchymal stem cell function in prolonged isolated thrombocytopenia post-allotransplant. 2018 Mar 2
18 29668110 Phenylbutyl isoselenocyanate induces reactive oxygen species to inhibit androgen receptor and to initiate p53-mediated apoptosis in LNCaP prostate cancer cells. 2018 Aug 1
19 30011295 Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways. 2018 1
20 30318520 Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2-· production in cancer cells. 2018 Oct 1
21 28653879 TP53 alteration determines the combinational cytotoxic effect of doxorubicin and an antioxidant NAC. 2017 Jun 4
22 26152521 Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. 2016 Jun 1
23 26756900 COX-2 inhibitor NS-398 suppresses doxorubicin-induced p53 accumulation through inhibition of ROS-mediated Jnk activation. 2016 Dec 1
24 26859482 Robust DNA Damage Response and Elevated Reactive Oxygen Species in TINF2-Mutated Dyskeratosis Congenita Cells. 2016 3
25 26934645 Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells. 2016 Mar 29 1
26 26936454 Carnosic acid induces apoptosis through inactivation of Src/STAT3 signaling pathway in human renal carcinoma Caki cells. 2016 May 2
27 27270209 Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation. 2016 Jun 8 1
28 27620489 Heme oxygenase-1-mediated apoptosis under cadmium-induced oxidative stress is regulated by autophagy, which is sensitized by tumor suppressor p53. 2016 Oct 7 1
29 27633119 A novel polysaccharide derived from algae extract induces apoptosis and cell cycle arrest in human gastric carcinoma MKN45 cells via ROS/JNK signaling pathway. 2016 Oct 1
30 25607831 CDK5RAP1 deficiency induces cell cycle arrest and apoptosis in human breast cancer cell line by the ROS/JNK signaling pathway. 2015 Mar 2
31 26264138 Overexpression of yeast thioredoxin TRX2 reduces p53-mediated cell death in yeast. 2015 Oct 1
32 26408691 Zinc Induces Apoptosis of Human Melanoma Cells, Increasing Reactive Oxygen Species, p53 and FAS Ligand. 2015 Oct 1
33 24477002 Antioxidants accelerate lung cancer progression in mice. 2014 Jan 29 1
34 24734887 Protective effect of N-acetylcysteine (NAC) on renal ischemia/reperfusion injury through Nrf2 signaling pathway. 2014 Oct 1
35 25369051 Phospho-aspirin-2 (MDC-22) inhibits estrogen receptor positive breast cancer growth both in vitro and in vivo by a redox-dependent effect. 2014 1
36 23124852 Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production. 2013 Feb 1
37 23128467 N-acetylcysteine potentiates doxorubicin-induced ATM and p53 activation in ovarian cancer cells. 2013 Jan 3
38 23792775 Role of direct reactivity with metals in chemoprotection by N-acetylcysteine against chromium(VI), cadmium(II), and cobalt(II). 2013 Dec 1
39 23841076 The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53. 2013 2
40 23867003 Targeting 3-phosphoinositide-dependent protein kinase 1 by N-acetyl-cysteine through activation of peroxisome proliferators activated receptor alpha in human lung cancer cells, the role of p53 and p65. 2013 Jul 18 3
41 24099794 Novel compound 1,3-bis (3,5-dichlorophenyl) urea inhibits lung cancer progression. 2013 Dec 15 1
42 22085531 A butyrolactone derivative suppressed lipopolysaccharide-induced autophagic injury through inhibiting the autoregulatory loop of p8 and p53 in vascular endothelial cells. 2012 Feb 1
43 22283740 P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK. 2012 Mar 4
44 22294162 Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells. 2012 Apr 1
45 22509835 Quercetin enhancement of arsenic-induced apoptosis via stimulating ROS-dependent p53 protein ubiquitination in human HaCaT keratinocytes. 2012 May 1
46 22537194 Molecular mechanism implicated in Pemetrexed-induced apoptosis in human melanoma cells. 2012 Apr 26 2
47 22982566 Hypoxia, Mn-SOD and H(2)O(2) regulate p53 reactivation and PRIMA-1 toxicity irrespective of p53 status in human breast cancer cells. 2012 Dec 15 1
48 20171194 Inhibition of calcium-independent phospholipase A2 activates p38 MAPK signaling pathways during cytostasis in prostate cancer cells. 2010 Jun 15 1
49 20653475 Antioxidant N-acetyl-cysteine protects retinal pigmented epithelial cells from long-term hypoxia changes in gene expression. 2010 Aug 1
50 19202565 Molecular mechanism of diallyl disulfide in cell cycle arrest and apoptosis in HCT-116 colon cancer cells. 2009 Jan-Feb 1