Polycyclic Aromatic Hydrocarbons

tumor protein p53 ; Homo sapiens







40 Article(s)
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1 35204761 Correlation of Occupational Exposure to Carcinogenic Polycyclic Aromatic Hydrocarbons (cPAHs) and Blood Levels of p53 and p21 Proteins. 2022 Feb 5 1
2 31815681 A lex naturalis delineates components of a human-specific, adrenal androgen-dependent, p53-mediated 'kill switch' tumor suppression mechanism. 2020 Feb 1
3 30553920 A novel computational solution to the health risk assessment of air pollution via joint toxicity prediction: A case study on selected PAH binary mixtures in particulate matters. 2019 Apr 15 1
4 30904656 PM2.5- and PM10-bound polycyclic aromatic hydrocarbons (PAHs) in the residential area near coal-fired power and steelmaking plants of Taichung City, Taiwan: In vitro-based health risk and source identification. 2019 Jun 20 1
5 29471073 The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells. 2018 Apr 1 1
6 28426525 GSTM1 and GSTT1 Genes are Associated With DNA Damage of p53 Gene in Coke-oven Workers. 2017 Jun 1
7 25398514 Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism. 2016 Feb 4
8 24798859 Regulation of p53-targeting microRNAs by polycyclic aromatic hydrocarbons: Implications in the etiology of multiple myeloma. 2015 Oct 2
9 24246761 Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway. 2014 Jan 25 1
10 24736433 p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling. 2014 Jun 2
11 24761888 Impact of AhR, CYP1A1 and GSTM1 genetic polymorphisms on TP53 R273G mutations in individuals exposed to polycyclic aromatic hydrocarbons. 2014 7
12 21887816 Classification of polycyclic aromatic hydrocarbons based on mutagenicity in lung tissue through DNA microarray. 2013 Nov 2
13 23692869 DNA synthesis inhibition in response to benzo[a]pyrene dihydrodiol epoxide is associated with attenuation of p(34)cdc2: Role of p53. 2013 Jul 4 2
14 22945568 Exposure to polycyclic aromatic hydrocarbons: bulky DNA adducts and cellular responses. 2012 4
15 21457773 Characterization of human breast cancer cell lines for the studies on p53 in chemical carcinogenesis. 2011 Aug 1
16 19892797 Shorter telomere length in peripheral blood lymphocytes of workers exposed to polycyclic aromatic hydrocarbons. 2010 Feb 1
17 20064791 Associations between polycyclic aromatic hydrocarbon-related exposures and p53 mutations in breast tumors. 2010 Apr 1
18 20064835 Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. 2010 Apr 2
19 20932552 Evaluation of the noncovalent binding interactions between polycyclic aromatic hydrocarbon metabolites and human p53 cDNA. 2010 Nov 15 3
20 18096571 Mdm2 as a sensitive and mechanistically informative marker for genotoxicity induced by benzo[a]pyrene and dibenzo[a,l]pyrene. 2008 Apr 1
21 17408702 Air pollution by carcinogenic PAHs and plasma levels of p53 and p21(WAF1) proteins. 2007 Jul 1 1
22 16427050 Activation of p53 as a causal step for atherosclerosis induced by polycyclic aromatic hydrocarbons. 2006 Feb 6 3
23 17030796 Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair. 2006 Oct 17 4
24 15564291 Detection of p53 and K-ras mutations in sputum of individuals exposed to smoky coal emissions in Xuan Wei County, China. 2005 Feb 1
25 12538356 Simulated sunlight and benzo[a]pyrene diol epoxide induced mutagenesis in the human p53 gene evaluated by the yeast functional assay: lack of correspondence to tumor mutation spectra. 2003 Jan 1
26 12711114 Comparison of p53 mutations between adenocarcinoma and squamous cell carcinoma of the lung: unique spectra involving G to A transitions and G to T transversions in both histologic types. 2003 May 3
27 12727806 Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells. 2003 Apr 2
28 12734332 Environmental chemical-induced pro/pre-B cell apoptosis: analysis of c-Myc, p27Kip1, and p21WAF1 reveals a death pathway distinct from clonal deletion. 2003 May 15 1
29 12379456 On the origin of p53 G:C --> T:A transversions in lung cancers. 2002 Oct 31 2
30 12379884 Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers. 2002 Oct 21 1
31 11238174 Patterns of p53 G-->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke. 2001 Mar 2
32 11505223 Impact of GSTM1 on aromatic-DNA adducts and p53 accumulation in human skin and lymphocytes. 2001 Aug 1
33 11559534 Lung tumor KRAS and TP53 mutations in nonsmokers reflect exposure to PAH-rich coal combustion emissions. 2001 Sep 15 1
34 11585742 Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-associated lung cancers. 2001 Oct 1 1
35 10636867 A novel DNA damage checkpoint involving post-transcriptional regulation of cyclin A expression. 2000 Jan 21 1
36 10814675 Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons. 2000 May 17 1
37 10837373 Polycyclic aromatic hydrocarbon carcinogens increase ubiquitination of p21 protein after the stabilization of p53 and the expression of p21. 2000 Jun 2
38 9881702 The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts. 1998 Dec 10 1
39 8692233 Comparative synchronous fluorescence spectrophotometry and 32P-postlabeling analysis of PAH-DNA adducts in human lung and the relationship to TP53 mutations. 1996 Jul 5 1
40 7586163 Mutation spectrum of cigarette smoke condensate in Salmonella: comparison to mutations in smoking-associated tumors. 1995 Oct 1