Title : Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells.

Pub. Date : 2003 Apr

PMID : 12727806






2 Functional Relationships(s)
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1 It has been reported that lung cancer from workers exposed to Cr(VI) has a high percentage of G to T transversion mutations in the non-transcribed strand of the p53 gene, a hallmark of PAH-induced mutation. Polycyclic Aromatic Hydrocarbons tumor protein p53 Homo sapiens
2 These results raise the possibility that Cr(VI) may enhance PAH binding at the p53 gene in lung tissue. Polycyclic Aromatic Hydrocarbons tumor protein p53 Homo sapiens