Pub. Date : 2016 Feb
PMID : 25398514
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism. | Polycyclic Aromatic Hydrocarbons | tumor protein p53 | Homo sapiens |
| 2 | We have investigated the role of TP53 in cytochrome P450 (CYP)-mediated metabolic activation of three polycyclic aromatic hydrocarbons (PAHs) in a panel of isogenic colorectal HCT116 cells with differing TP53 status. | Polycyclic Aromatic Hydrocarbons | tumor protein p53 | Homo sapiens |
| 3 | We have investigated the role of TP53 in cytochrome P450 (CYP)-mediated metabolic activation of three polycyclic aromatic hydrocarbons (PAHs) in a panel of isogenic colorectal HCT116 cells with differing TP53 status. | Polycyclic Aromatic Hydrocarbons | tumor protein p53 | Homo sapiens |
| 4 | Bypass of the need for metabolic activation by treating cells with the corresponding reactive PAH-diol-epoxide metabolites resulted in similar adduct levels in all cell lines, which confirms that the influence of p53 is on the metabolism of the parent PAHs. | Polycyclic Aromatic Hydrocarbons | tumor protein p53 | Homo sapiens |