triptolide

MCL1 apoptosis regulator, BCL2 family member ; Homo sapiens







14 Article(s)
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1 31972422 Prediction of triptolide targets in rheumatoid arthritis using network pharmacology and molecular docking. 2020 Mar 3
2 31115521 Triptolide exerts an anti-tumor effect on non‑small cell lung cancer cells by inhibiting activation of the IL‑6/STAT3 axis. 2019 Jul 1
3 25875797 Primary and liver metastasis-derived cell lines from KrasG12D; Trp53R172H; Pdx-1 Cre animals undergo apoptosis in response to triptolide. 2015 May 1
4 24481531 Triptolide induces apoptotic cell death of multiple myeloma cells via transcriptional repression of Mcl-1. 2014 Apr 5
5 24742042 Triptolide induces apoptotic cell death of human cholangiocarcinoma cells through inhibition of myeloid cell leukemia-1. 2014 Apr 17 2
6 24025188 miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death. 2013 Sep 11 3
7 21904380 MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML. 2012 Mar 1
8 22033489 Activation of apoptosis signaling eliminates CD34+ progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors. 2012 Apr 1
9 19942343 Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1. 2010 May 28 3
10 20878065 Triptolide inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway. 2010 Nov 3
11 19240172 Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation. 2009 Mar 1 1
12 19383029 Activity of triptolide against human mast cells harboring the kinase domain mutant KIT. 2009 Jul 1
13 19671059 Triptolide abrogates oncogene FIP1L1-PDGFRalpha addiction and induces apoptosis in hypereosinophilic syndrome. 2009 Nov 1
14 19723894 Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells. 2009 Sep 1