Title : Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1.

Pub. Date : 2010 May 28

PMID : 19942343






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1. triptolide MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 Triptolide induced abundant apoptosis with a prominent decline of Bcl-2, Bcl-X(L), survivin and Mcl-1. triptolide MCL1 apoptosis regulator, BCL2 family member Homo sapiens
3 As well, triptolide induced caspase-3-dependent Mcl-1 cleavage, which may potentiate apoptosis. triptolide MCL1 apoptosis regulator, BCL2 family member Homo sapiens