Pub. Date : 2013 Sep 11
PMID : 24025188
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Decrease of Mcl-1 levels, either by siRNA or by treatment with triptolide results in cell death. | triptolide | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 2 | Over-expression of miR-204, either by a miR-204 mimic, or by triptolide treatment results in a decrease in Mcl-1 levels, and a subsequent decrease in cell viability. | triptolide | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 3 | CONCLUSION: Triptolide mediated miR-204 increase causes pancreatic cancer cell death via loss of Mcl-1. | triptolide | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |