| 1 |
32998965 | Phase I Study of Alvocidib Followed by 7+3 (Cytarabine + Daunorubicin) in Newly Diagnosed Acute Myeloid Leukemia. | 2021 Jan 1 |
1 |
| 2 |
34718324 | A prospective biomarker analysis of alvocidib followed by cytarabine and mitoxantrone in MCL-1-dependent relapsed/refractory acute myeloid leukemia. | 2021 Oct 30 |
1 |
| 3 |
30815228 | Myeloid cell leukemia-1 dependence in acute myeloid leukemia: a novel approach to patient therapy. | 2019 Feb 8 |
2 |
| 4 |
29287727 | Upregulation of Mcl-1 inhibits JQ1-triggered anticancer activity in hepatocellular carcinoma cells. | 2018 Jan 22 |
1 |
| 5 |
28404924 | Antitumor effects of cyclin dependent kinase 9 inhibition in esophageal adenocarcinoma. | 2017 Apr 25 |
2 |
| 6 |
28663057 | Inhibition of Mcl-1 enhances Pevonedistat-triggered apoptosis in osteosarcoma cells. | 2017 Sep 15 |
1 |
| 7 |
29291023 | Combined venetoclax and alvocidib in acute myeloid leukemia. | 2017 Dec 5 |
1 |
| 8 |
25596730 | Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia. | 2015 Feb 20 |
2 |
| 9 |
26565405 | Loss in MCL-1 function sensitizes non-Hodgkin's lymphoma cell lines to the BCL-2-selective inhibitor venetoclax (ABT-199). | 2015 Nov 13 |
1 |
| 10 |
24735445 | Multiplex analysis of anti-apoptotic BCL2 family and caspase 3 activation by microbead arrays. | 2014 Apr |
1 |
| 11 |
23515411 | A phase I trial of vorinostat and alvocidib in patients with relapsed, refractory, or poor prognosis acute leukemia, or refractory anemia with excess blasts-2. | 2013 Apr 1 |
1 |
| 12 |
23825534 | IL-6 regulates Mcl-1L expression through the JAK/PI3K/Akt/CREB signaling pathway in hepatocytes: implication of an anti-apoptotic role during liver regeneration. | 2013 |
2 |
| 13 |
22276149 | Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis. | 2012 |
1 |
| 14 |
22693249 | CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies. | 2012 Aug 15 |
1 |
| 15 |
22829255 | Targeting MCL-1 sensitizes FLT3-ITD-positive leukemias to cytotoxic therapies. | 2012 Mar |
1 |
| 16 |
21768777 | Vinblastine sensitizes leukemia cells to cyclin-dependent kinase inhibitors, inducing acute cell cycle phase-independent apoptosis. | 2011 Aug 15 |
1 |
| 17 |
21821698 | ABT-737 induces apoptosis in mantle cell lymphoma cells with a Bcl-2high/Mcl-1low profile and synergizes with other antineoplastic agents. | 2011 Sep 15 |
1 |
| 18 |
20197552 | Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1. | 2010 Apr 22 |
1 |
| 19 |
20444920 | Human chorionic gonadotropin up-regulates expression of myeloid cell leukemia-1 protein in human granulosa-lutein cells: implication of corpus luteum rescue and ovarian hyperstimulation syndrome. | 2010 Aug |
1 |
| 20 |
19509251 | Expression levels of p18INK4C modify the cellular efficacy of cyclin-dependent kinase inhibitors via regulation of Mcl-1 expression in tumor cell lines. | 2009 Jun |
1 |
| 21 |
18192508 | Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium. | 2008 Mar 15 |
1 |
| 22 |
17308065 | Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions. | 2007 Feb |
6 |
| 23 |
18065490 | Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells. | 2007 Dec |
1 |
| 24 |
16432172 | Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy. | 2006 Jan |
1 |
| 25 |
16503551 | Flavopiridol in patients with relapsed or refractory multiple myeloma: a phase 2 trial with clinical and pharmacodynamic end-points. | 2006 Mar |
1 |
| 26 |
16624404 | Induction of apoptosis and down regulation of cell cycle proteins in mantle cell lymphoma by flavopiridol treatment. | 2006 Nov |
1 |
| 27 |
16740725 | Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells. | 2006 Jun 1 |
1 |
| 28 |
15150106 | Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells. | 2004 May 15 |
1 |
| 29 |
15235103 | Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol. | 2004 Oct |
1 |
| 30 |
15634644 | The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism. | 2004 Dec |
1 |
| 31 |
12533675 | Flavopiridol-induced apoptosis is mediated through up-regulation of E2F1 and repression of Mcl-1. | 2003 Jan |
6 |
| 32 |
14562039 | Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process. | 2003 Oct 16 |
1 |
| 33 |
14633785 | Advances in biology and therapy of multiple myeloma. | 2003 |
1 |
| 34 |
11792416 | Growth inhibition and apoptosis of myeloma cells by the CDK inhibitor flavopiridol. | 2002 Mar |
1 |
| 35 |
12231544 | Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells. | 2002 Sep |
1 |
| 36 |
12429644 | The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1. | 2002 Nov |
5 |
| 37 |
11472347 | Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia. | 2001 Jul |
1 |
| 38 |
10887097 | Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia. | 2000 Jul 15 |
2 |