Title : Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process.

Pub. Date : 2003 Oct 16

PMID : 14562039






1 Functional Relationships(s)
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1 In U937 cells, synergistic interactions between MG-132 and flavopiridol were associated with multiple perturbations in expression/activation of signaling- and survival-related proteins, including downregulation of XIAP and Mcl-1, activation of JNK and p34(cdc2), and diminished expression of p21(CIP1). alvocidib MCL1 apoptosis regulator, BCL2 family member Homo sapiens