Title : Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia.

Pub. Date : 2015 Feb 20

PMID : 25596730






2 Functional Relationships(s)
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1 Herein, we present that this resistant cell line developed resistance through up-regulation of phosphorylation of RNA polymerase II C-terminal domain, activation of CDK9 kinase activity, and prolonged Mcl-1 stability to counter flavopiridol"s drug actions. alvocidib MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 Further analyses suggest MAPK/ERK activation-mediated Mcl-1 stabilization contributes to the resistance and knockdown of Mcl-1 in part restores sensitivity to flavopiridol-induced cytotoxicity. alvocidib MCL1 apoptosis regulator, BCL2 family member Homo sapiens