| 1 |
35257833 | GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer. | 2022 May 28 |
4 |
| 2 |
35385296 | Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging. | 2022 Apr 8 |
6 |
| 3 |
32928708 | KHK-A promotes the proliferation of oesophageal squamous cell carcinoma through the up-regulation of PRPS1. | 2021 Mar |
2 |
| 4 |
33490936 | Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis. | 2021 Apr |
4 |
| 5 |
33621267 | Prevalence and cardiometabolic correlates of ketohexokinase gene variants among UK Biobank participants. | 2021 |
1 |
| 6 |
34069635 | Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells. | 2021 May 19 |
1 |
| 7 |
34409309 | A luminescence-based protocol for assessing fructose metabolism via quantification of ketohexokinase enzymatic activity in mouse or human hepatocytes. | 2021 Sep 17 |
2 |
| 8 |
34487756 | Endogenous fructose is correlated with urinary albumin creatinine ratios and uric acid in type 2 diabetes mellitus. | 2021 Sep |
1 |
| 9 |
32775322 | Computational Modeling of Fructose Metabolism and Development in NAFLD. | 2020 |
1 |
| 10 |
32883877 | Fruit setting rewires central metabolism via gibberellin cascades. | 2020 Sep 22 |
1 |
| 11 |
32910646 | Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose. | 2020 Nov 25 |
4 |
| 12 |
33057854 | Tissue-Specific Fructose Metabolism in Obesity and Diabetes. | 2020 Oct 15 |
2 |
| 13 |
30798914 | Fructose-associated hepatotoxicity indexed by the lactate dehydrogenase isoenzyme LDH-5. | 2019 Mar |
2 |
| 14 |
31487794 | The Potential for Renal Injury Elicited by Physical Work in the Heat. | 2019 Sep 4 |
1 |
| 15 |
29020416 | Fructose metabolism, cardiometabolic risk, and the epidemic of coronary artery disease. | 2018 Jul 7 |
3 |
| 16 |
29616058 | Plant Fructokinases: Evolutionary, Developmental, and Metabolic Aspects in Sink Tissues. | 2018 |
6 |
| 17 |
29664676 | A mathematical analysis of adaptations to the metabolic fate of fructose in essential fructosuria subjects. | 2018 Sep 1 |
3 |
| 18 |
29870677 | Ketohexokinase knockout mice, a model for essential fructosuria, exhibit altered fructose metabolism and are protected from diet-induced metabolic defects. | 2018 Sep 1 |
3 |
| 19 |
30031605 | Ketohexokinase is involved in fructose utilization and promotes tumor progression in glioma. | 2018 Sep 10 |
5 |
| 20 |
28407885 | The sweetest thing: blocking fructose metabolism to prevent acute kidney injury? | 2017 May |
1 |
| 21 |
28853885 | Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK). | 2017 Sep 28 |
4 |
| 22 |
27322374 | Bioactivity-Guided Identification of Botanical Inhibitors of Ketohexokinase. | 2016 |
4 |
| 23 |
27387598 | The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis. | 2016 Oct |
1 |
| 24 |
27879401 | Diabetic Cardiomyopathy: The Case for a Role of Fructose in Disease Etiology. | 2016 Dec |
1 |
| 25 |
25187370 | Adiponectin resistance and proinflammatory changes in the visceral adipose tissue induced by fructose consumption via ketohexokinase-dependent pathway. | 2015 Feb |
2 |
| 26 |
26521124 | Pharmacophore modeling, virtual screening, molecular docking studies and density functional theory approaches to identify novel ketohexokinase (KHK) inhibitors. | 2015 Dec |
5 |
| 27 |
25079017 | Cyclical dehydration-induced renal injury and Mesoamerican nephropathy: as sweet by any other name? | 2014 Aug |
1 |
| 28 |
23762544 | Fructose: a key factor in the development of metabolic syndrome and hypertension. | 2013 |
2 |
| 29 |
23112875 | Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver. | 2012 |
5 |
| 30 |
23229602 | [Uric acid and the prevention of renal and cardiovascular disease in CKD]. | 2012 Nov-Dec |
1 |
| 31 |
24900346 | Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. | 2011 Jul 14 |
3 |
| 32 |
19158351 | Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. | 2009 Mar |
4 |
| 33 |
19237742 | Structures of alternatively spliced isoforms of human ketohexokinase. | 2009 Mar |
3 |
| 34 |
18395287 | Fructose consumption as a risk factor for non-alcoholic fatty liver disease. | 2008 Jun |
3 |
| 35 |
16372272 | The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma. | 2006 Feb |
1 |
| 36 |
12941785 | Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria. | 2003 Sep |
2 |
| 37 |
11264590 | Expression, purification and preliminary crystallographic studies of human ketohexokinase. | 2001 Apr |
1 |
| 38 |
11079825 | Effects of oral D-tagatose, a stereoisomer of D-fructose, on liver metabolism in man as examined by 31P-magnetic resonance spectroscopy. | 2000 Oct |
1 |
| 39 |
9799106 | Structure and alternative splicing of the ketohexokinase gene. | 1998 Oct 1 |
3 |
| 40 |
8662230 | Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of chromosome 2p23. | 1996 Jun |
1 |
| 41 |
8330752 | Peripheral nerve protein glycation and muscle fructolysis: evidence of abnormal carbohydrate metabolism in ALS. | 1993 Jan-Feb |
1 |
| 42 |
2826162 | Fructose metabolism via the pentose cycle in tumoral islet cells. | 1987 Dec 30 |
1 |
| 43 |
2996495 | The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol. | 1985 Aug 15 |
1 |
| 44 |
6416107 | Enzymatic analysis of 2,5-anhydro-D-mannitol and related compounds. | 1983 Sep |
1 |
| 45 |
6284103 | Models for the metabolic production of oxalate from xylitol in humans: a role for fructokinase and aldolase. | 1982 Feb |
1 |
| 46 |
16640 | Determination of the rate-limiting steps and chemical mechanism of fructokinase by isotope exchange, isotope partitioning, and pH studies. | 1977 May 17 |
1 |
| 47 |
4579754 | Control of hepatic fructose-metabolizing enzymes: fructokinase, aldolase and triokinase. | 1972 |
1 |
| 48 |
4385849 | Enzymes of fructose metabolism in human liver. | 1968 Aug |
1 |