Title : Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver.

Pub. Date : 2012

PMID : 23112875






5 Functional Relationships(s)
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1 The first step in fructose metabolism is mediated by fructokinase (KHK), which phosphorylates fructose to fructose-1-phosphate; intracellular uric acid is also generated as a consequence of the transient ATP depletion that occurs during this reaction. Fructose ketohexokinase Homo sapiens
2 The first step in fructose metabolism is mediated by fructokinase (KHK), which phosphorylates fructose to fructose-1-phosphate; intracellular uric acid is also generated as a consequence of the transient ATP depletion that occurs during this reaction. Fructose ketohexokinase Homo sapiens
3 The first step in fructose metabolism is mediated by fructokinase (KHK), which phosphorylates fructose to fructose-1-phosphate; intracellular uric acid is also generated as a consequence of the transient ATP depletion that occurs during this reaction. Fructose ketohexokinase Homo sapiens
4 The first step in fructose metabolism is mediated by fructokinase (KHK), which phosphorylates fructose to fructose-1-phosphate; intracellular uric acid is also generated as a consequence of the transient ATP depletion that occurs during this reaction. Fructose ketohexokinase Homo sapiens
5 Here we show in human hepatocytes that uric acid up-regulates KHK expression thus leading to the amplification of the lipogenic effects of fructose. Fructose ketohexokinase Homo sapiens