Pub. Date : 2022 May 28
PMID : 35257833
4 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer. | Fructose | ketohexokinase | Homo sapiens | ||
| 2 | Mechanistically, in glucose-deprived but fructose-rich environments, GLUT5 could interact with ketohexokinase and inhibit its autophagy-dependent degradation, thus trapping fructose into glycolysis and tricarboxylic acid cycle for the malignant growth of CRC cells. | Fructose | ketohexokinase | Homo sapiens | ||
| 3 | Taken together, our findings highlight the role of elevated fructose utilization mediated by the GLUT5-KHK axis in governing CRC growth and imply that efforts to refine fructose intake or inhibit fructose-mediated actions may serve as potential therapeutic strategies. | Fructose | ketohexokinase | Homo sapiens | ||
| 4 | Taken together, our findings highlight the role of elevated fructose utilization mediated by the GLUT5-KHK axis in governing CRC growth and imply that efforts to refine fructose intake or inhibit fructose-mediated actions may serve as potential therapeutic strategies. | Fructose | ketohexokinase | Homo sapiens | ||