PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11079825-1 2000 D-tagatose, which is a stereoisomer of D-fructose, is phosphorylated to D-tagatose-1-phosphate by fructokinase in the liver. Fructose 39-49 ketohexokinase Homo sapiens 98-110 19237742-2 2009 Fructose catabolism is initiated by its phosphorylation to fructose 1-phosphate, which is performed by ketohexokinase (KHK). Fructose 0-8 ketohexokinase Homo sapiens 103-117 19237742-2 2009 Fructose catabolism is initiated by its phosphorylation to fructose 1-phosphate, which is performed by ketohexokinase (KHK). Fructose 0-8 ketohexokinase Homo sapiens 119-122 19158351-0 2009 Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. Fructose 39-47 ketohexokinase Homo sapiens 0-14 19158351-2 2009 Once in the cell, fructose is phosphorylated by ketohexokinase (KHK), leading to consumption of ATP, formation of AMP, and generation of uric acid through xanthine oxidoreductase (XOR). Fructose 18-26 ketohexokinase Homo sapiens 48-62 19158351-2 2009 Once in the cell, fructose is phosphorylated by ketohexokinase (KHK), leading to consumption of ATP, formation of AMP, and generation of uric acid through xanthine oxidoreductase (XOR). Fructose 18-26 ketohexokinase Homo sapiens 64-67 19158351-3 2009 This study aimed to examine the direct effects of fructose in human kidney proximal tubular cells (HK-2) and whether they are mediated by the fructose metabolism via KHK. Fructose 142-150 ketohexokinase Homo sapiens 166-169 18395287-7 2008 In patients with NAFLD (n=6), hepatic mRNA expression of fructokinase (KHK), an important enzyme for fructose metabolism, and fatty acid synthase, an important enzyme for lipogenesis were increased (p=0.04 and p=0.02, respectively). Fructose 101-109 ketohexokinase Homo sapiens 57-69 18395287-7 2008 In patients with NAFLD (n=6), hepatic mRNA expression of fructokinase (KHK), an important enzyme for fructose metabolism, and fatty acid synthase, an important enzyme for lipogenesis were increased (p=0.04 and p=0.02, respectively). Fructose 101-109 ketohexokinase Homo sapiens 71-74 16372272-2 2006 Ketohexokinase (also called fructokinase), which catalyzes the phosphorylation of fructose to fructose 1-phosphate, was identified by MALDI-TOF MS and found to be expressed at low rates in the renal tumor tissues. Fructose 82-90 ketohexokinase Homo sapiens 0-14 12941785-6 2003 Ketohexokinase-A has much poorer substrate affinity than ketohexokinase-C for fructose but is considerably more thermostable. Fructose 78-86 ketohexokinase Homo sapiens 0-14 12941785-6 2003 Ketohexokinase-A has much poorer substrate affinity than ketohexokinase-C for fructose but is considerably more thermostable. Fructose 78-86 ketohexokinase Homo sapiens 57-71 11264590-3 2001 KHK is the first enzyme in a specialized catabolic pathway metabolizing dietary fructose to the glycolytic intermediate glyceraldehyde-3-phosphate. Fructose 80-88 ketohexokinase Homo sapiens 0-3 24900346-1 2011 Attenuation of fructose metabolism by the inhibition of ketohexokinase (KHK; fructokinase) should reduce body weight, free fatty acids, and triglycerides, thereby offering a novel approach to treat diabetes and obesity in response to modern diets. Fructose 15-23 ketohexokinase Homo sapiens 56-70 24900346-1 2011 Attenuation of fructose metabolism by the inhibition of ketohexokinase (KHK; fructokinase) should reduce body weight, free fatty acids, and triglycerides, thereby offering a novel approach to treat diabetes and obesity in response to modern diets. Fructose 15-23 ketohexokinase Homo sapiens 72-75 24900346-1 2011 Attenuation of fructose metabolism by the inhibition of ketohexokinase (KHK; fructokinase) should reduce body weight, free fatty acids, and triglycerides, thereby offering a novel approach to treat diabetes and obesity in response to modern diets. Fructose 15-23 ketohexokinase Homo sapiens 77-89 19237742-4 2009 The structure of the KHK-A ternary complex revealed an active site with both the substrate fructose and the ATP analogue in positions ready for phosphorylation following a reaction mechanism similar to that of the pfkB family of carbohydrate kinases. Fructose 91-99 ketohexokinase Homo sapiens 21-24 18395287-8 2008 In an AML hepatocyte cell line, fructose resulted in dose-dependent increase in KHK protein and activity. Fructose 32-40 ketohexokinase Homo sapiens 80-83 34487756-8 2021 CONCLUSION: Fasting serum fructose and KHK in endogenous fructose are associated with serum uric acid and urinary albumin levels in patients with T2DM. Fructose 57-65 ketohexokinase Homo sapiens 39-42 8662230-5 1996 KHK is the first enzyme of the specialized pathway that catabolizes dietary fructose. Fructose 76-84 ketohexokinase Homo sapiens 0-3 8330752-4 1993 Evidence is also presented showing increased activities of ketohexokinase and F-1-P splitting aldolase, which suggests that further metabolism of fructose may occur via a fructolytic pathway. Fructose 146-154 ketohexokinase Homo sapiens 59-73 9799106-1 1998 Ketohexokinase (fructokinase, KHK) catalyses the phosphorylation of fructose to fructose-l-phosphate. Fructose 68-76 ketohexokinase Homo sapiens 0-14 9799106-1 1998 Ketohexokinase (fructokinase, KHK) catalyses the phosphorylation of fructose to fructose-l-phosphate. Fructose 68-76 ketohexokinase Homo sapiens 16-28 9799106-1 1998 Ketohexokinase (fructokinase, KHK) catalyses the phosphorylation of fructose to fructose-l-phosphate. Fructose 68-76 ketohexokinase Homo sapiens 30-33 34069635-5 2021 Fructose, by itself, did not increase intracellular lipid content nor aggravated the effects of palmitic acid (PA) or free fatty acids mixture (FFA), although it led to an up-expression of hepatic fructokinase. Fructose 0-8 ketohexokinase Homo sapiens 189-209 34409309-1 2021 Ketohexokinase (KHK) catalyzes the first step of fructose metabolism. Fructose 49-57 ketohexokinase Homo sapiens 0-14 34409309-1 2021 Ketohexokinase (KHK) catalyzes the first step of fructose metabolism. Fructose 49-57 ketohexokinase Homo sapiens 16-19 2826162-1 1987 In tumoral islet cells (RINm5F line) the phosphorylation of D-fructose is catalyzed by hexokinase rather than fructokinase. Fructose 60-70 ketohexokinase Homo sapiens 110-122 35257833-0 2022 GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer. Fructose 24-32 ketohexokinase Homo sapiens 6-9 35257833-6 2022 Mechanistically, in glucose-deprived but fructose-rich environments, GLUT5 could interact with ketohexokinase and inhibit its autophagy-dependent degradation, thus trapping fructose into glycolysis and tricarboxylic acid cycle for the malignant growth of CRC cells. Fructose 173-181 ketohexokinase Homo sapiens 95-109 35257833-8 2022 Taken together, our findings highlight the role of elevated fructose utilization mediated by the GLUT5-KHK axis in governing CRC growth and imply that efforts to refine fructose intake or inhibit fructose-mediated actions may serve as potential therapeutic strategies. Fructose 60-68 ketohexokinase Homo sapiens 103-106 35257833-8 2022 Taken together, our findings highlight the role of elevated fructose utilization mediated by the GLUT5-KHK axis in governing CRC growth and imply that efforts to refine fructose intake or inhibit fructose-mediated actions may serve as potential therapeutic strategies. Fructose 196-204 ketohexokinase Homo sapiens 103-106 35385296-0 2022 Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging. Fructose 24-32 ketohexokinase Homo sapiens 0-14 35385296-1 2022 The ability to break down fructose is dependent on ketohexokinase (KHK) that phosphorylates fructose to fructose-1-phosphate (F1P). Fructose 26-34 ketohexokinase Homo sapiens 51-65 35385296-1 2022 The ability to break down fructose is dependent on ketohexokinase (KHK) that phosphorylates fructose to fructose-1-phosphate (F1P). Fructose 26-34 ketohexokinase Homo sapiens 67-70 35385296-1 2022 The ability to break down fructose is dependent on ketohexokinase (KHK) that phosphorylates fructose to fructose-1-phosphate (F1P). Fructose 92-100 ketohexokinase Homo sapiens 51-65 35385296-1 2022 The ability to break down fructose is dependent on ketohexokinase (KHK) that phosphorylates fructose to fructose-1-phosphate (F1P). Fructose 92-100 ketohexokinase Homo sapiens 67-70 35385296-4 2022 KHK overexpression in liver cancer cells results in decreased fructose flux through glycolysis. Fructose 62-70 ketohexokinase Homo sapiens 0-3 2996495-7 1985 The kinetic properties of ketohexokinase show that this enzyme can phosphorylate D-xylulose as readily as D-fructose, except that higher concentrations of D-xylulose are required. Fructose 106-116 ketohexokinase Homo sapiens 26-40 6284103-2 1982 It is shown in this paper that fructokinase and aldolase, purified from human liver, provide an alternative model in that, in coupled sequence, they produce glycolaldehyde, an oxalate precursor, from D-xylulose via D-xylulose 1-phosphate; D-fructose does not give rise to glycolaldehyde. Fructose 239-249 ketohexokinase Homo sapiens 31-43 6416107-7 1983 The fructokinase procedure allows the measurement of fructose, 2,5-anhydromannitol, 2,5-anhydroglucitol, and 2,5-anhydrotalitol. Fructose 53-61 ketohexokinase Homo sapiens 4-16 16640-1 1977 Isotope exchange studies show that beef liver fructokinase has a random kinetic mechanism in which release of fructose from the enzyme is slower than that catalytic reaction. Fructose 110-118 ketohexokinase Homo sapiens 46-58 32928708-1 2021 BACKGROUND AND STUDY AIMS: The metabolism of dietary fructose by ketohexokinase (KHK) is an important step in glucose metabolism in various tumour types. Fructose 53-61 ketohexokinase Homo sapiens 65-79 4579754-0 1972 Control of hepatic fructose-metabolizing enzymes: fructokinase, aldolase and triokinase. Fructose 19-27 ketohexokinase Homo sapiens 50-62 4385849-6 1968 The rate of fructose uptake from the blood, as described by other investigators, can be based on the activity of ketohexokinase reported in the present paper. Fructose 12-20 ketohexokinase Homo sapiens 113-127 32928708-1 2021 BACKGROUND AND STUDY AIMS: The metabolism of dietary fructose by ketohexokinase (KHK) is an important step in glucose metabolism in various tumour types. Fructose 53-61 ketohexokinase Homo sapiens 81-84 33490936-1 2021 Background & Aims: Increasing evidence highlights dietary fructose as a major driver of non-alcoholic fatty liver disease (NAFLD) pathogenesis, the majority of which is cleared on first pass through the hepatic circulation by enzymatic phosphorylation to fructose-1-phosphate via the ketohexokinase (KHK) enzyme. Fructose 58-66 ketohexokinase Homo sapiens 300-303 33490936-0 2021 Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis. Fructose 52-60 ketohexokinase Homo sapiens 0-14 33490936-1 2021 Background & Aims: Increasing evidence highlights dietary fructose as a major driver of non-alcoholic fatty liver disease (NAFLD) pathogenesis, the majority of which is cleared on first pass through the hepatic circulation by enzymatic phosphorylation to fructose-1-phosphate via the ketohexokinase (KHK) enzyme. Fructose 58-66 ketohexokinase Homo sapiens 284-298 33621267-1 2021 Essential fructosuria (EF) is a benign, asymptomatic, autosomal recessive condition caused by loss-of-function variants in the ketohexokinase gene and characterized by intermittent appearance of fructose in the urine. Fructose 195-203 ketohexokinase Homo sapiens 127-141 32910646-0 2020 Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose. Fructose 143-151 ketohexokinase Homo sapiens 48-62 32910646-0 2020 Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose. Fructose 143-151 ketohexokinase Homo sapiens 64-67 32910646-2 2020 Ketohexokinase (KHK) converts fructose to fructose-1-phosphate (F1P) in the first step of the metabolic cascade. Fructose 30-38 ketohexokinase Homo sapiens 0-14 32910646-2 2020 Ketohexokinase (KHK) converts fructose to fructose-1-phosphate (F1P) in the first step of the metabolic cascade. Fructose 30-38 ketohexokinase Homo sapiens 16-19 33490936-8 2021 Human co-cultures exposed to fructose exhibit steatosis and activation of lipogenic and fibrogenic gene expression, which were reduced by pharmacological inhibition of KHK activity. Fructose 29-37 ketohexokinase Homo sapiens 168-171 32883877-7 2020 Moreover, fruit set at least partly required the activity of fructokinase, which may pull fructose out of the vacuole, and this could feed the downstream pathways. Fructose 90-98 ketohexokinase Homo sapiens 61-73 33057854-6 2020 Skeletal muscle and adipose tissue can also metabolize a large portion of fructose load, especially in the setting of ketohexokinase deficiency, the rate-limiting enzyme of fructose metabolism. Fructose 74-82 ketohexokinase Homo sapiens 118-132 33057854-6 2020 Skeletal muscle and adipose tissue can also metabolize a large portion of fructose load, especially in the setting of ketohexokinase deficiency, the rate-limiting enzyme of fructose metabolism. Fructose 173-181 ketohexokinase Homo sapiens 118-132 31487794-8 2019 Heightened fructokinase pathway activity likely exacerbates ATP depletion occurring secondary to intrarenal fructose production and hyperuricemia. Fructose 108-116 ketohexokinase Homo sapiens 11-23 32775322-14 2020 The simulations of fructokinase suppression provide a good model for potentially reversing simple steatosis induced by high fructose consumption, which can be corroborated by experimental studies. Fructose 124-132 ketohexokinase Homo sapiens 19-31 30031605-4 2018 Meanwhile, we detected the effect of silencing KHK on the biological functions of glioma cells in fructose medium. Fructose 98-106 ketohexokinase Homo sapiens 47-50 30798914-3 2019 After entering hepatocytes via insulin-independent glucose transporter 2 transmembrane carrier proteins, fructose is phosphorylated to fructose-1-phosphate in a reaction catalysed by fructokinase (ketohexokinase). Fructose 105-113 ketohexokinase Homo sapiens 183-195 30798914-3 2019 After entering hepatocytes via insulin-independent glucose transporter 2 transmembrane carrier proteins, fructose is phosphorylated to fructose-1-phosphate in a reaction catalysed by fructokinase (ketohexokinase). Fructose 105-113 ketohexokinase Homo sapiens 197-211 30031605-0 2018 Ketohexokinase is involved in fructose utilization and promotes tumor progression in glioma. Fructose 30-38 ketohexokinase Homo sapiens 0-14 30031605-6 2018 Functionally, knockdown of KHK could significantly inhibit cell proliferation and migration of glioma cells in fructose medium. Fructose 111-119 ketohexokinase Homo sapiens 27-30 30031605-7 2018 Furthermore, we investigated the KHK expression level after long-time treatment with fructose, and detected the change of cell biological behaviour, then we found that the expression level of KHK was significantly increased and these cells showed more malignant properties. Fructose 85-93 ketohexokinase Homo sapiens 33-36 30031605-7 2018 Furthermore, we investigated the KHK expression level after long-time treatment with fructose, and detected the change of cell biological behaviour, then we found that the expression level of KHK was significantly increased and these cells showed more malignant properties. Fructose 85-93 ketohexokinase Homo sapiens 192-195 29870677-2 2018 Hereditary deficiency of ketohexokinase (KHK), the first enzymatic step in fructose metabolism, leads to essential fructosuria in humans, characterized by elevated levels of blood and urinary fructose following fructose ingestion but is otherwise clinically benign. Fructose 75-83 ketohexokinase Homo sapiens 41-44 29664676-2 2018 In response to an oral challenge, the majority of fructose is cleared during "first-pass" liver metabolism, primarily via phosphorylation by ketohexokinase (KHK). Fructose 50-58 ketohexokinase Homo sapiens 141-155 29664676-2 2018 In response to an oral challenge, the majority of fructose is cleared during "first-pass" liver metabolism, primarily via phosphorylation by ketohexokinase (KHK). Fructose 50-58 ketohexokinase Homo sapiens 157-160 29664676-3 2018 A rare benign genetic deficiency in KHK, called essential fructosuria (EF), leads to altered fructose metabolism. Fructose 93-101 ketohexokinase Homo sapiens 36-39 29870677-2 2018 Hereditary deficiency of ketohexokinase (KHK), the first enzymatic step in fructose metabolism, leads to essential fructosuria in humans, characterized by elevated levels of blood and urinary fructose following fructose ingestion but is otherwise clinically benign. Fructose 192-200 ketohexokinase Homo sapiens 41-44 29870677-2 2018 Hereditary deficiency of ketohexokinase (KHK), the first enzymatic step in fructose metabolism, leads to essential fructosuria in humans, characterized by elevated levels of blood and urinary fructose following fructose ingestion but is otherwise clinically benign. Fructose 192-200 ketohexokinase Homo sapiens 41-44 29020416-4 2018 In these organs, fructose metabolism is initiated by ketohexokinase (KHK) isoform C of the central fructose-metabolizing enzyme KHK. Fructose 17-25 ketohexokinase Homo sapiens 53-67 29020416-4 2018 In these organs, fructose metabolism is initiated by ketohexokinase (KHK) isoform C of the central fructose-metabolizing enzyme KHK. Fructose 17-25 ketohexokinase Homo sapiens 69-72 29020416-4 2018 In these organs, fructose metabolism is initiated by ketohexokinase (KHK) isoform C of the central fructose-metabolizing enzyme KHK. Fructose 17-25 ketohexokinase Homo sapiens 128-131 29616058-3 2018 Both sucrose-cleaving enzymes yield free fructose, which must be phosphorylated by either fructokinase (FRK) or hexokinase (HXK). Fructose 41-49 ketohexokinase Homo sapiens 90-102 29616058-3 2018 Both sucrose-cleaving enzymes yield free fructose, which must be phosphorylated by either fructokinase (FRK) or hexokinase (HXK). Fructose 41-49 ketohexokinase Homo sapiens 104-107 29616058-4 2018 The affinity of FRK to fructose is much higher than that of HXK, making FRKs central for fructose metabolism. Fructose 23-31 ketohexokinase Homo sapiens 16-19 29616058-4 2018 The affinity of FRK to fructose is much higher than that of HXK, making FRKs central for fructose metabolism. Fructose 89-97 ketohexokinase Homo sapiens 16-19 29616058-7 2018 Plant FRK enzymes vary in their biochemical properties such as affinity for fructose, inhibition by their substrate (i.e., fructose), and expression level in different tissues. Fructose 76-84 ketohexokinase Homo sapiens 6-9 29616058-7 2018 Plant FRK enzymes vary in their biochemical properties such as affinity for fructose, inhibition by their substrate (i.e., fructose), and expression level in different tissues. Fructose 123-131 ketohexokinase Homo sapiens 6-9 28407885-2 2017 A recent study published in Nature Communications demonstrates a reduction in ischemic acute kidney injury with genetic knockout or inhibition of fructokinase, which catalyzes the first step in fructose metabolism. Fructose 194-202 ketohexokinase Homo sapiens 146-158 28853885-2 2017 Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, identification of a selective KHK inhibitor may help to further elucidate the effect of KHK inhibition on these metabolic disorders. Fructose 67-75 ketohexokinase Homo sapiens 6-20 28853885-2 2017 Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, identification of a selective KHK inhibitor may help to further elucidate the effect of KHK inhibition on these metabolic disorders. Fructose 67-75 ketohexokinase Homo sapiens 22-25 28853885-2 2017 Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, identification of a selective KHK inhibitor may help to further elucidate the effect of KHK inhibition on these metabolic disorders. Fructose 67-75 ketohexokinase Homo sapiens 118-121 28853885-2 2017 Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, identification of a selective KHK inhibitor may help to further elucidate the effect of KHK inhibition on these metabolic disorders. Fructose 67-75 ketohexokinase Homo sapiens 118-121 27879401-7 2016 Exciting recent discoveries link heart failure to induction of the specific high-affinity fructose-metabolizing enzyme, fructokinase, in an experimental setting. Fructose 90-98 ketohexokinase Homo sapiens 120-132 27387598-3 2016 Acutely, fructose increases de novo lipogenesis through the efficient and uninhibited action of ketohexokinase and aldolase B which yields substrates for fatty-acid synthesis. Fructose 9-17 ketohexokinase Homo sapiens 96-110 27322374-3 2016 Recent studies have shown that ketohexokinase isoform C is the key enzyme responsible in fructose metabolism that drive"s fructose"s adverse effects. Fructose 89-97 ketohexokinase Homo sapiens 31-45 27322374-3 2016 Recent studies have shown that ketohexokinase isoform C is the key enzyme responsible in fructose metabolism that drive"s fructose"s adverse effects. Fructose 122-130 ketohexokinase Homo sapiens 31-45 27322374-7 2016 Two different extract lots of the top botanical candidates were further evaluated in lysates of HepG2 cells overexpressing ketohexokinase-C for inhibition of fructose-induced ATP depletion. Fructose 158-166 ketohexokinase Homo sapiens 123-137 27322374-12 2016 CONCLUSIONS: Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis were the top four botanical candidiates identified with inhibitory activity against ketohexokinase-C. Future studies are needed to show proof of mechanism and the efficacy of these botanical extracts in humans to blunt the negative metabolic effects of fructose-containing added sugars. Fructose 360-368 ketohexokinase Homo sapiens 191-205 23112875-3 2012 The first step in fructose metabolism is mediated by fructokinase (KHK), which phosphorylates fructose to fructose-1-phosphate; intracellular uric acid is also generated as a consequence of the transient ATP depletion that occurs during this reaction. Fructose 18-26 ketohexokinase Homo sapiens 53-65 25187370-2 2015 In mammalian cells, fructose is metabolized predominantly via phosphorylation to fructose-1 phosphate by ketohexokinase (KHK) or by alternative pathways. Fructose 20-28 ketohexokinase Homo sapiens 105-119 25187370-2 2015 In mammalian cells, fructose is metabolized predominantly via phosphorylation to fructose-1 phosphate by ketohexokinase (KHK) or by alternative pathways. Fructose 20-28 ketohexokinase Homo sapiens 121-124 23762544-6 2013 Fructose is metabolized by fructokinase (KHK). Fructose 0-8 ketohexokinase Homo sapiens 27-39 23762544-6 2013 Fructose is metabolized by fructokinase (KHK). Fructose 0-8 ketohexokinase Homo sapiens 41-44 26521124-1 2015 Fructose catabolism starts with phosphorylation of d-fructose to fructose 1-phosphate, which is performed by ketohexokinase (KHK). Fructose 0-8 ketohexokinase Homo sapiens 109-123 26521124-1 2015 Fructose catabolism starts with phosphorylation of d-fructose to fructose 1-phosphate, which is performed by ketohexokinase (KHK). Fructose 0-8 ketohexokinase Homo sapiens 125-128 26521124-1 2015 Fructose catabolism starts with phosphorylation of d-fructose to fructose 1-phosphate, which is performed by ketohexokinase (KHK). Fructose 51-61 ketohexokinase Homo sapiens 109-123 26521124-1 2015 Fructose catabolism starts with phosphorylation of d-fructose to fructose 1-phosphate, which is performed by ketohexokinase (KHK). Fructose 51-61 ketohexokinase Homo sapiens 125-128 26521124-3 2015 The inhibition of KHK has medicinally potential roles in fructose metabolism and the metabolic syndrome. Fructose 57-65 ketohexokinase Homo sapiens 18-21 25079017-2 2014 This effect is attenuated by global fructokinase deficiency, suggesting possible roles for fructokinase and fructose metabolism in mediating or promoting dehydration-induced injury. Fructose 108-116 ketohexokinase Homo sapiens 36-48 23229602-4 2012 Also fructose raises the uric acid concentration as a result of the activation of fructokinase with ATP consumption and stimulation of AP deaminase. Fructose 5-13 ketohexokinase Homo sapiens 82-94 23112875-3 2012 The first step in fructose metabolism is mediated by fructokinase (KHK), which phosphorylates fructose to fructose-1-phosphate; intracellular uric acid is also generated as a consequence of the transient ATP depletion that occurs during this reaction. Fructose 94-102 ketohexokinase Homo sapiens 67-70 23112875-4 2012 Here we show in human hepatocytes that uric acid up-regulates KHK expression thus leading to the amplification of the lipogenic effects of fructose. Fructose 139-147 ketohexokinase Homo sapiens 62-65 23112875-3 2012 The first step in fructose metabolism is mediated by fructokinase (KHK), which phosphorylates fructose to fructose-1-phosphate; intracellular uric acid is also generated as a consequence of the transient ATP depletion that occurs during this reaction. Fructose 18-26 ketohexokinase Homo sapiens 67-70 23112875-3 2012 The first step in fructose metabolism is mediated by fructokinase (KHK), which phosphorylates fructose to fructose-1-phosphate; intracellular uric acid is also generated as a consequence of the transient ATP depletion that occurs during this reaction. Fructose 94-102 ketohexokinase Homo sapiens 53-65