Disulfiram

aldehyde dehydrogenase 1 family member A1 ; Homo sapiens







18 Article(s)
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1 35056791 Novel Disulfiram Derivatives as ALDH1a1-Selective Inhibitors. 2022 Jan 12 7
2 35125923 ALDH1A1 Gene Expression and Cellular Copper Levels between Low and Highly Metastatic Osteosarcoma Provide a Case for Novel Repurposing with Disulfiram and Copper. 2022 1
3 35372040 Disulfiram Transcends ALDH Inhibitory Activity When Targeting Ovarian Cancer Tumor-Initiating Cells. 2022 1
4 33744437 Development of new disulfiram analogues as ALDH1a1-selective inhibitors. 2021 May 15 4
5 34580061 ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor Cells to Promote Breast Cancer Progression. 2021 Dec 1 1
6 32600223 Cancer Pro-oxidant Therapy Through Copper Redox Cycling: Repurposing Disulfiram and Tetrathiomolybdate. 2020 1
7 31596733 Disulfiram suppressed ethanol promoted RANKL-induced osteoclastogenesis in vitro and ethanol-induced osteoporosis in vivo via ALDH1A1-NFATc1 axis. 2019 Oct 8 2
8 29665144 Disulfiram/copper targets stem cell-like ALDH+ population of multiple myeloma by inhibition of ALDH1A1 and Hedgehog pathway. 2018 Aug 2
9 29069808 Targeting the cancer stem cell marker, aldehyde dehydrogenase 1, to circumvent cisplatin resistance in NSCLC. 2017 Sep 22 1
10 27542268 Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells. 2016 Sep 6 1
11 26193988 Characterization of the metabolism of benzaldehyde dimethane sulfonate (NSC 281612, DMS612). 2015 Sep 1
12 21487404 Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties. 2011 May 10 1
13 19296407 Molecular cloning and oxidative modification of human lens ALDH1A1: implication in impaired detoxification of lipid aldehydes. 2009 1
14 9354647 Inhibition of recombinant human mitochondrial and cytosolic aldehyde dehydrogenases by two candidates for the active metabolites of disulfiram. 1997 Nov 4 1
15 8562935 Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer. 1996 Feb 1 2
16 8605194 Possible role of liver cytosolic and mitochondrial aldehyde dehydrogenases in acetaldehyde metabolism. 1996 Apr 9 1
17 7779080 The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme. 1995 Jun 6 1
18 6634868 Interaction of human cytoplasmic aldehyde dehydrogenase E1 with disulfiram. 1983 2