PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9354647-2 1997 Disulfiram, MeDTC sulfoxide, and MeDTC sulfone, respectively, were potent inhibitors with IC50 values of 0.15 +/- 0.02 microM, 0.27 +/- 0.04 microM, and 0.12 +/- 0.02 microM for ALDH1, and 1.45 +/- 0.40 microM, 1.16 +/- 0.56, and 0.40 +/- 0.10 microM for ALDH2. Disulfiram 0-10 aldehyde dehydrogenase 1 family member A1 Homo sapiens 178-183 19296407-5 2009 Citral, disulfiram, and cyanamide were found to inhibit human lens ALDH1A1 at IC50 values of 55, 101, and 22610 microM, respectively, whereas diethylstilbestrol (DES) was found to be an activator (EC(50), 1.3 microM). Disulfiram 8-18 aldehyde dehydrogenase 1 family member A1 Homo sapiens 67-74 8562935-5 1996 The resistant phenotype was specifically caused by ALDH1 overexpression as shown by its reversion by disulfiram, a specific ALDH1 inhibitor. Disulfiram 101-111 aldehyde dehydrogenase 1 family member A1 Homo sapiens 51-56 8605194-6 1996 In vitro human ALDH-1 is 10 times less sensitive to disulfiram inhibition than are the hamster and rat cytosolic ALDHs. Disulfiram 52-62 aldehyde dehydrogenase 1 family member A1 Homo sapiens 15-21 8562935-5 1996 The resistant phenotype was specifically caused by ALDH1 overexpression as shown by its reversion by disulfiram, a specific ALDH1 inhibitor. Disulfiram 101-111 aldehyde dehydrogenase 1 family member A1 Homo sapiens 124-129 31596733-0 2019 Disulfiram suppressed ethanol promoted RANKL-induced osteoclastogenesis in vitro and ethanol-induced osteoporosis in vivo via ALDH1A1-NFATc1 axis. Disulfiram 0-10 aldehyde dehydrogenase 1 family member A1 Homo sapiens 126-133 7779080-4 1995 This enzyme activity was insensitive to inhibition by disulfiram, a potent inhibitor of ALDH1. Disulfiram 54-64 aldehyde dehydrogenase 1 family member A1 Homo sapiens 88-93 35372040-9 2022 Comparison of disulfiram to the direct targeting of ALDH1A1 with the NCTs suggests that the broader cellular effects of disulfiram are more suitable as a therapeutic to eradicate TICs from tumors and prevent EOC relapse. Disulfiram 120-130 aldehyde dehydrogenase 1 family member A1 Homo sapiens 52-59 33744437-0 2021 Development of new disulfiram analogues as ALDH1a1-selective inhibitors. Disulfiram 19-29 aldehyde dehydrogenase 1 family member A1 Homo sapiens 43-50 33744437-4 2021 Disulfiram also inhibits ALDH1a1, another member of the aldehyde dehydrogenases that catalyzes the oxidation of retinal into retinoic acid. Disulfiram 0-10 aldehyde dehydrogenase 1 family member A1 Homo sapiens 25-32 33744437-7 2021 Thus, replacing disulfiram ethyl groups with larger groups will yield selective ALDH1a1 inhibitors. Disulfiram 16-26 aldehyde dehydrogenase 1 family member A1 Homo sapiens 80-87 33744437-9 2021 The 2b derivative showed a comparable activity to disulfiram against ALDH1a1; however, it was completely devoid of inhibitory activity against ALDH2. Disulfiram 50-60 aldehyde dehydrogenase 1 family member A1 Homo sapiens 69-76 32600223-12 2020 The potential of disulfiram or its metabolically active Cu-containing form, to inhibit ALDH1-positive tumor cells is therapeutically very important. Disulfiram 17-27 aldehyde dehydrogenase 1 family member A1 Homo sapiens 87-92 31596733-6 2019 Overall, our study provides promising evidence that disulfiram can be used as a treatment strategy for alcohol-related osteoporosis via the ALDH1A1T-NFATc1 axis. Disulfiram 52-62 aldehyde dehydrogenase 1 family member A1 Homo sapiens 140-147 34580061-6 2021 Furthermore, the ALDH1A1 inhibitor disulfiram and chemotherapeutic agent gemcitabine cooperatively inhibited breast tumor growth and tumorigenesis by purging ALDH+ TICs and activating T cell immunity. Disulfiram 35-45 aldehyde dehydrogenase 1 family member A1 Homo sapiens 17-24 35125923-0 2022 ALDH1A1 Gene Expression and Cellular Copper Levels between Low and Highly Metastatic Osteosarcoma Provide a Case for Novel Repurposing with Disulfiram and Copper. Disulfiram 140-150 aldehyde dehydrogenase 1 family member A1 Homo sapiens 0-7 35056791-0 2022 Novel Disulfiram Derivatives as ALDH1a1-Selective Inhibitors. Disulfiram 6-16 aldehyde dehydrogenase 1 family member A1 Homo sapiens 32-39 35056791-2 2022 Drugs that can inhibit ALDH1a1 include disulfiram, an FDA-approved drug to treat chronic alcoholism. Disulfiram 39-49 aldehyde dehydrogenase 1 family member A1 Homo sapiens 23-30 35056791-3 2022 Disulfiram, by carbamylation of the catalytic cysteines, irreversibly inhibits ALDH1a1 and ALDH2. Disulfiram 0-10 aldehyde dehydrogenase 1 family member A1 Homo sapiens 79-86 35056791-5 2022 Given the fact that ALDH1a1 has a larger substrate tunnel than that in ALDH2, replacing disulfiram ethyl groups with larger motifs will yield selective ALDH1a1 inhibitors. Disulfiram 88-98 aldehyde dehydrogenase 1 family member A1 Homo sapiens 20-27 35056791-5 2022 Given the fact that ALDH1a1 has a larger substrate tunnel than that in ALDH2, replacing disulfiram ethyl groups with larger motifs will yield selective ALDH1a1 inhibitors. Disulfiram 88-98 aldehyde dehydrogenase 1 family member A1 Homo sapiens 152-159 35056791-6 2022 We report herein the synthesis of new inhibitors of ALDH1a1 where (hetero)aromatic rings were introduced into the structure of disulfiram. Disulfiram 127-137 aldehyde dehydrogenase 1 family member A1 Homo sapiens 52-59 35056791-7 2022 Most of the developed compounds retained the anti-ALDH1a1 activity of disulfiram; however, they were completely devoid of inhibitory activity against ALDH2. Disulfiram 70-80 aldehyde dehydrogenase 1 family member A1 Homo sapiens 50-57 6634868-1 1983 Two equivalents of symmetrically labeled [14C]-disulfiram (tetraethylthiuram disulfide, Antabuse) interact with human liver cytoplasmic aldehyde dehydrogenase (ALDH) E1 (E.C. Disulfiram 59-86 aldehyde dehydrogenase 1 family member A1 Homo sapiens 136-168 6634868-1 1983 Two equivalents of symmetrically labeled [14C]-disulfiram (tetraethylthiuram disulfide, Antabuse) interact with human liver cytoplasmic aldehyde dehydrogenase (ALDH) E1 (E.C. Disulfiram 88-96 aldehyde dehydrogenase 1 family member A1 Homo sapiens 136-168 29069808-11 2017 Targeting ALDH1 with Diethylaminobenzaldehyde (DEAB) and Disulfiram, significantly re-sensitized resistant lung cancer cells to the cytotoxic effects of cisplatin. Disulfiram 57-67 aldehyde dehydrogenase 1 family member A1 Homo sapiens 10-15 29665144-0 2018 Disulfiram/copper targets stem cell-like ALDH+ population of multiple myeloma by inhibition of ALDH1A1 and Hedgehog pathway. Disulfiram 0-10 aldehyde dehydrogenase 1 family member A1 Homo sapiens 95-102 29665144-11 2018 Our data suggest that DS/Cu can inhibit the ALDH+ stem cell-like cells through ALDH1A1 and Hh pathway, which may be a promising therapeutic agent in eradicating stem cell-like cells of MM. Disulfiram 22-24 aldehyde dehydrogenase 1 family member A1 Homo sapiens 79-86 27542268-0 2016 Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells. Disulfiram 21-31 aldehyde dehydrogenase 1 family member A1 Homo sapiens 10-17 26193988-11 2015 The conversion was inhibited by disulfiram, an inhibitor of ALDH. Disulfiram 32-42 aldehyde dehydrogenase 1 family member A1 Homo sapiens 60-64 21487404-11 2011 Mammosphere formation and the ALDH1(+VE) and CD24(Low)/CD44(High) CSCs population in mammospheres were significantly inhibited by exposure to DS/Cu for 24 h. Disulfiram/copper induced reactive oxygen species (ROS) generation and activated its downstream apoptosis-related cJun N-terminal kinase and p38 MAPK pathways. Disulfiram 158-168 aldehyde dehydrogenase 1 family member A1 Homo sapiens 30-35