Pub. Date : 2022 Jan 12
PMID : 35056791
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Novel Disulfiram Derivatives as ALDH1a1-Selective Inhibitors. | Disulfiram | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 2 | Drugs that can inhibit ALDH1a1 include disulfiram, an FDA-approved drug to treat chronic alcoholism. | Disulfiram | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 3 | Disulfiram, by carbamylation of the catalytic cysteines, irreversibly inhibits ALDH1a1 and ALDH2. | Disulfiram | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 4 | Given the fact that ALDH1a1 has a larger substrate tunnel than that in ALDH2, replacing disulfiram ethyl groups with larger motifs will yield selective ALDH1a1 inhibitors. | Disulfiram | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 5 | Given the fact that ALDH1a1 has a larger substrate tunnel than that in ALDH2, replacing disulfiram ethyl groups with larger motifs will yield selective ALDH1a1 inhibitors. | Disulfiram | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 6 | We report herein the synthesis of new inhibitors of ALDH1a1 where (hetero)aromatic rings were introduced into the structure of disulfiram. | Disulfiram | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 7 | Most of the developed compounds retained the anti-ALDH1a1 activity of disulfiram; however, they were completely devoid of inhibitory activity against ALDH2. | Disulfiram | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |