Pyrimidine Nucleotides

dihydroorotate dehydrogenase (quinone) ; Homo sapiens







13 Article(s)
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PMID
Title
Pub. Year
#Total Relationships
1 35223511 Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia. 2022 2
2 35492218 Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication. 2022 May 20 1
3 33249060 The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines. 2021 Jan 15 1
4 33571819 Leflunomide an immunomodulator with antineoplastic and antiviral potentials but drug-induced liver injury: A comprehensive review. 2021 Apr 1
5 34462431 Therapeutic targeting of both dihydroorotate dehydrogenase and nucleoside transport in MYCN-amplified neuroblastoma. 2021 Aug 30 1
6 31499527 Discovery of a new pyrimidine synthesis inhibitor eradicating glioblastoma-initiating cells. 2020 Feb 20 1
7 30347213 Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer. 2019 Mar 1
8 30974126 Suppression of pyrimidine biosynthesis by targeting DHODH enzyme robustly inhibits rotavirus replication. 2019 Jul 1
9 31391321 Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells. 2019 Aug 7 1
10 17369345 Functional expression of human dihydroorotate dehydrogenase (DHODH) in pyr4 mutants of ustilago maydis allows target validation of DHODH inhibitors in vivo. 2007 May 1
11 17094333 Leflunomide in clinical practice. 2006 Jul-Sep 1
12 15571245 Severe impairment of nucleotide synthesis through inhibition of mitochondrial respiration. 2004 Oct 2
13 10889450 Indirect inhibition of mitochondrial dihydroorotate dehydrogenase activity by nitric oxide. 2000 Apr 15 1