PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17369345-2	2007	DHODH is an important target for antiparasitic and cytostatic drugs since rapid cell proliferation often depends on the de novo synthesis of pyrimidine nucleotides.	Pyrimidine Nucleotides	141-163	dihydroorotate dehydrogenase (quinone)	Homo sapiens	0-5	
15571245-1	2004	Since de-novo synthesis of pyrimidine nucleotides is coupled to the mitochondrial respiratory chain (RC) via dehydroorotic acid dehydrogenase (DHODH), respiratory chain dysfunction should impair pyrimidine synthesis.	Pyrimidine Nucleotides	27-49	dihydroorotate dehydrogenase (quinone)	Homo sapiens	109-141	
17094333-1	2006	Leflunomide (LEF) is a prodrug that is rapidly converted to its active metabolite A77 1726, that inhibits the novo pyrimidine nucleotide biosynthesis, mediated especially by the dihydroorotate dehidrogenase (DHODH).	Pyrimidine Nucleotides	115-136	dihydroorotate dehydrogenase (quinone)	Homo sapiens	178-206	
15571245-1	2004	Since de-novo synthesis of pyrimidine nucleotides is coupled to the mitochondrial respiratory chain (RC) via dehydroorotic acid dehydrogenase (DHODH), respiratory chain dysfunction should impair pyrimidine synthesis.	Pyrimidine Nucleotides	27-49	dihydroorotate dehydrogenase (quinone)	Homo sapiens	143-148	
30974126-8	2019	Mechanistic study indicated that BQR and LFM exerted their anti-rotavirus effect through targeting DHODH to deplete pyrimidine nucleotide pool.	Pyrimidine Nucleotides	116-137	dihydroorotate dehydrogenase (quinone)	Homo sapiens	99-104	
10889450-6	2000	Since orotate is the precursor of all pyrimidine nucleotides, indirect inhibition of DHODH by NO may significantly contribute to NO-dependent cytotoxicity.	Pyrimidine Nucleotides	38-60	dihydroorotate dehydrogenase (quinone)	Homo sapiens	85-90	
35492218-5	2022	We propose that the lack of available pyrimidine nucleotides upon DHODH inhibition increases the incorporation of NHC into nascent viral RNA.	Pyrimidine Nucleotides	38-60	dihydroorotate dehydrogenase (quinone)	Homo sapiens	66-71	
35223511-1	2022	Blocking the pyrimidine nucleotide de novo synthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH) results in the cell cycle arrest and/or differentiation of rapidly proliferating cells including activated lymphocytes, cancer cells, or virally infected cells.	Pyrimidine Nucleotides	13-34	dihydroorotate dehydrogenase (quinone)	Homo sapiens	75-103	
35223511-1	2022	Blocking the pyrimidine nucleotide de novo synthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH) results in the cell cycle arrest and/or differentiation of rapidly proliferating cells including activated lymphocytes, cancer cells, or virally infected cells.	Pyrimidine Nucleotides	13-34	dihydroorotate dehydrogenase (quinone)	Homo sapiens	105-110	
33571819-2	2021	DHODH is a mitochondrial inner membrane enzyme responsible for catalytic conversion of dihydroorotate into orotate, a rate-limiting step in the de novo synthesis of the pyrimidine nucleotides.	Pyrimidine Nucleotides	169-191	dihydroorotate dehydrogenase (quinone)	Homo sapiens	0-5	
33249060-2	2021	Here, we describe the anti-COVID-19 potential of PTC299, an orally bioavailable compound that is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), the rate-limiting enzyme of the de novo pyrimidine nucleotide biosynthesis pathway.	Pyrimidine Nucleotides	197-218	dihydroorotate dehydrogenase (quinone)	Homo sapiens	149-154	
34462431-4	2021	Gene expression profiling and metabolomic analysis reveal that MYCN promotes pyrimidine nucleotide production by transcriptional upregulation of DHODH and other enzymes of the pyrimidine-synthesis pathway.	Pyrimidine Nucleotides	77-98	dihydroorotate dehydrogenase (quinone)	Homo sapiens	145-150	
31499527-7	2020	Mechanistic studies revealed that 10580 decreased pyrimidine nucleotide levels and enhanced SOX2 nuclear export by antagonizing the enzyme activity of DHODH, an essential enzyme for de novo pyrimidine synthesis.	Pyrimidine Nucleotides	50-71	dihydroorotate dehydrogenase (quinone)	Homo sapiens	151-156	
31391321-3	2019	Targeting the pyrimidine synthetic rate-limiting step enzyme carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, dihydroorotase (CAD) or the critical downstream enzyme dihydroorotate dehydrogenase (DHODH) inhibited GSC survival, self-renewal, and in vivo tumor initiation through the depletion of the pyrimidine nucleotide supply in rodent models.	Pyrimidine Nucleotides	311-332	dihydroorotate dehydrogenase (quinone)	Homo sapiens	178-206	
30347213-5	2019	Inhibition of DHODH depletes intracellular pyrimidine nucleotide pools and results in cell cycle arrest in S-phase, sensitization to current chemotherapies, and differentiation in neural crest cells and acute myeloid leukemia (AML).	Pyrimidine Nucleotides	43-64	dihydroorotate dehydrogenase (quinone)	Homo sapiens	14-19