Phosphotyrosine

Cbl proto-oncogene ; Homo sapiens







39 Article(s)
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1 33512474 CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1. 2021 Apr 22 2
2 33620036 Sleuthing biochemical evidence to elucidate unassigned electron density in a CBL-SLAP2 crystal complex. 2021 Feb 1 1
3 29498112 Phosphorylation control of the ubiquitin ligase Cbl is conserved in choanoflagellates. 2018 May 1
4 26264748 Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells. 2015 Aug 12 1
5 24113870 Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis. 2013 Dec 5 1
6 21163258 An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding. 2011 Jan 21 1
7 19183301 Systems biology of growth factor-induced receptor endocytosis. 2009 Apr 1
8 18273061 Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates. 2008 Mar 5 1
9 17449471 Specific Grb2-mediated interactions regulate clathrin-dependent endocytosis of the cMet-tyrosine kinase. 2007 Jun 8 2
10 17620338 Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation. 2007 Oct 5 2
11 17635922 Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase. 2007 Sep 14 1
12 17094785 Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl. 2006 Dec 1
13 15536084 Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase. 2005 Jan 14 1
14 15737992 Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins. 2005 May 13 4
15 15123609 A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation. 2004 Jul 9 1
16 15190072 Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation. 2004 Aug 27 2
17 15465819 Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment. 2004 Dec 31 1
18 15475003 Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation. 2004 Nov 1 1
19 15556646 Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl. 2004 Nov 19 2
20 12802274 c-Cbl is a critical modulator of the Ron tyrosine kinase receptor. 2003 Jun 12 1
21 12839496 Epidermal growth factor receptor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation. 2003 Aug 1
22 11713248 The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1. 2002 Feb 8 1
23 11133830 The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation. 2001 Jan 1
24 11493652 c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route. 2001 Jun 1
25 11494134 Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor. 2001 Jul 5 2
26 9988765 Activation of nuclear factor of activated T cells-(NFAT) and activating protein 1 (AP-1) by oncogenic 70Z Cbl requires an intact phosphotyrosine binding domain but not Crk(L) or p85 phosphatidylinositol 3-kinase association. 1999 Feb 19 4
27 10078535 Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. 1999 Mar 4 1
28 10348664 Oxidative stress oppositely modulates protein tyrosine phosphorylation stimulated by muscarinic G protein-coupled and epidermal growth factor receptors. 1999 Feb 1 1
29 10362357 cbl-3: a new mammalian cbl family protein. 1999 Jun 3 1
30 10490604 The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells. 1999 Oct 4
31 10521482 Leucine zipper-mediated homodimerization of the adaptor protein c-Cbl. A role in c-Cbl's tyrosine phosphorylation and its association with epidermal growth factor receptor. 1999 Oct 22 4
32 9525940 Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells. 1998 Apr 3 2
33 9797470 c-Cbl: a regulator of T cell receptor-mediated signalling. 1998 Oct 1
34 8995358 Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase. 1997 Jan 10 3
35 9092538 Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif. 1997 Apr 11 2
36 9407100 The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. 1997 Dec 26 3
37 9570294 The Cbl protooncogene product: from an enigmatic oncogene to center stage of signal transduction. 1997 1
38 9622055 The Cbl family of signal transduction molecules. 1997 1
39 7629144 Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl. 1995 Aug 4 1