Title : Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates.

Pub. Date : 2008 Mar 5

PMID : 18273061






1 Functional Relationships(s)
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1 An obligatory, intrapeptidyl H-bond between the phosphotyrosine and the conserved asparagine or adjacent arginine is essential for binding and orients the peptide into a positively charged pocket on c-Cbl. Phosphotyrosine Cbl proto-oncogene Homo sapiens