Title : Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl.

Pub. Date : 2006 Dec

PMID : 17094785






1 Functional Relationships(s)
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1 In contrast, disabling the tyrosine kinase-binding domain of full-length Cbl by mutating glycine 306 to glutamic acid, and thereby preventing the previously described binding of the tyrosine kinase-binding domain to the Src phosphotyrosine 416, had no effect on Cbl phosphorylation, the inhibition of Src activity by full-length Cbl, or bone resorption. Phosphotyrosine Cbl proto-oncogene Homo sapiens