Benzo(a)pyrene

cytochrome P450 family 1 subfamily B member 1 ; Homo sapiens







67 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 35315151 Specific protection of sensitive skin against environmental stress by maintenance and improvement of barrier function. 2022 Apr 1
2 33991922 Mutagenicity risk prediction of PAH and derivative mixtures by in silico simulations oriented from CYP compound I-mediated metabolic activation. 2021 Sep 15 1
3 34439562 Curcumin Suppresses the Lipid Accumulation and Oxidative Stress Induced by Benzo[a]pyrene Toxicity in HepG2 Cells. 2021 Aug 20 1
4 32730838 Expression profile of cytochrome P450s and effects of polycyclic aromatic hydrocarbons and antiepileptic drugs on CYP1 expression in MOG-G-CCM cells. 2020 Oct 1 1
5 31092429 Diallyl Trisulfide Enhances Benzo[a]pyrene-induced CYP1A1 Expression and Metabolic Activation in Hepatic HepG2 Cells. 2019 May 1
6 31515600 Interleukin-6 selectively induces drug metabolism to potentiate the genotoxicity of dietary carcinogens in mammary cells. 2019 Oct 2
7 30137621 Aryl Hydrocarbon Receptor-Dependent Metabolism Plays a Significant Role in Estrogen-Like Effects of Polycyclic Aromatic Hydrocarbons on Cell Proliferation. 2018 Oct 1 1
8 28247504 Epigallocatechin-3-gallate augments the therapeutic effects of benzo[a]pyrene-mediated lung carcinogenesis. 2017 Jul 8 1
9 28405246 Modulation of benzo[a]pyrene-DNA adduct formation by CYP1 inducer and inhibitor. 2017 1
10 27486223 Divergent Ah Receptor Ligand Selectivity during Hominin Evolution. 2016 Oct 1
11 24695682 CYP1B1 mRNA inducibility due to benzo(a)pyrene is modified by the CYP1B1 L432V gene polymorphism. 2014 Jul 3
12 24736433 p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling. 2014 Jun 2
13 25199627 Hypoxia diminishes the detoxification of the environmental mutagen benzo[a]pyrene. 2014 Nov 1
14 25245543 Correlation between CYP1A1 transcript, protein level, enzyme activity and DNA adduct formation in normal human mammary epithelial cell strains exposed to benzo[a]pyrene. 2014 Nov 2
15 25658124 CYP1B1: a unique gene with unique characteristics. 2014 1
16 23325794 Genetic polymorphisms in catalase and CYP1B1 determine DNA adduct formation by benzo(a)pyrene ex vivo. 2013 Mar 1
17 21920623 ERĪ± phenotype, estrogen level, and benzo[a]pyrene exposure modulate tumor growth and metabolism of lung adenocarcinoma cells. 2012 Mar 1
18 22374940 Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis. 2012 Apr 1
19 21028851 Regulation of benzo[a]pyrene-mediated DNA- and glutathione-adduct formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human lung cells. 2011 Jan 14 1
20 21507987 Detoxification: a novel function of BRCA1 in tumor suppression? 2011 Jul 1
21 21669939 The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene-DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene. 2011 Sep 4
22 19879933 Importance of CYP1A1 and CYP1B1 in bioactivation of benzo[a]pyrene in human lung cell lines. 2010 Feb 1 1
23 19919601 Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin. 2010 Jan 1
24 20163913 CYP1A1 and CYP1B1 gene expression and DNA adduct formation in normal human mammary epithelial cells exposed to benzo[a]pyrene in the absence or presence of chlorophyllin. 2010 Jun 28 5
25 20399842 The critical DNA damage by benzo(a)pyrene in lung tissues of smokers and approaches to preventing its formation. 2010 Sep 15 1
26 19152381 Chlorophyllin significantly reduces benzo[a]pyrene-DNA adduct formation and alters cytochrome P450 1A1 and 1B1 expression and EROD activity in normal human mammary epithelial cells. 2009 Mar 2
27 19406224 Global transcriptional characterization of a mouse pulmonary epithelial cell line for use in genetic toxicology. 2009 Aug 1
28 17919675 Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. 2008 Feb 1 1
29 18336845 Transcriptional profiles of benzo(a)pyrene exposure in normal human mammary epithelial cells in the absence or presence of chlorophyllin. 2008 Apr 2 1
30 18372000 Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene. 2008 Jul 15 4
31 16530937 Cytochrome P450 1B1, a novel chemopreventive target for benzo[a]pyrene-initiated human esophageal cancer. 2007 Feb 8 1
32 17261025 Electrochemiluminescent arrays for cytochrome P450-activated genotoxicity screening. DNA damage from benzo[a]pyrene metabolites. 2007 Mar 1 1
33 16185837 In vitro cytotoxicity of polycyclic aromatic hydrocarbon residues arising through repeated fish fried oil in human hepatoma Hep G2 cell line. 2006 Apr 2
34 16226778 Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1. 2006 May 15 1
35 16237193 Preferential induction of CYP1A1 and CYP1B1 in CCSP-positive cells. 2006 Jan 1
36 16484233 Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids. 2006 Aug 2
37 15713371 Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cells. 2005 Mar 1 5
38 15735009 Altered gene expression patterns in MCF-7 cells induced by the urban dust particulate complex mixture standard reference material 1649a. 2005 Feb 15 1
39 15808407 Induction of CYP1A1 and CYP1B1 and formation of carcinogen-DNA adducts in normal human mammary epithelial cells treated with benzo[a]pyrene. 2005 Apr 28 2
40 15890477 Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells. 2005 Aug 14 2
41 15905203 Preferential induction of CYP1B1 by benzo[a]pyrene in human oral epithelial cells: impact on DNA adduct formation and prevention by polyphenols. 2005 Oct 3
42 15958554 Characterization of common CYP1B1 variants with different capacity for benzo[a]pyrene-7,8-dihydrodiol epoxide formation from benzo[a]pyrene. 2005 Jun 15 3
43 16120219 Responses of genes involved in cell cycle control to diverse DNA damaging chemicals in human lung adenocarcinoma A549 cells. 2005 Aug 24 1
44 16162842 Long-term effects of a standardized complex mixture of urban dust particulate on the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons in human cells in culture. 2005 Dec 2
45 15297370 Tobacco smoke induces CYP1B1 in the aerodigestive tract. 2004 Nov 1
46 11854143 Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite. 2002 Mar 1
47 11921196 Neoplastic transformation of human breast epithelial cells by estrogens and chemical carcinogens. 2002 1
48 12127040 Benzo(a)pyrene exposure induces CYP1A1 activity and expression in human endometrial cells. 2002 May 1
49 12183407 Genetic and environmental determinants on tissue response to in vitro carcinogen exposure and risk of breast cancer. 2002 Aug 15 1
50 12396873 Induction of cytochromes P-450 1A1 and 1B1 by motorcycle exhaust particulate in human breast cancer MCF-7 cells. 2002 Oct 11 1