Title : Characterization of common CYP1B1 variants with different capacity for benzo[a]pyrene-7,8-dihydrodiol epoxide formation from benzo[a]pyrene.

Pub. Date : 2005 Jun 15

PMID : 15958554






3 Functional Relationships(s)
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1 Characterization of common CYP1B1 variants with different capacity for benzo[a]pyrene-7,8-dihydrodiol epoxide formation from benzo[a]pyrene. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens
2 In this study, we have investigated CYP1B1 haplotypes present in a Spanish population and carried out functional analyses of the corresponding enzymes in yeast using benzo[a]pyrene as a substrate. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens
3 The variant CYP1B1 forms were heterologously expressed with human reductase in Saccharomyces cerevisiae and kinetic analyses of benzo[a]pyrene metabolism were carried out. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens