Title : The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene-DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene.

Pub. Date : 2011 Sep

PMID : 21669939






4 Functional Relationships(s)
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1 The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens
2 The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens
3 The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens
4 Therefore, during 96 h of exposure in MCF-7 cells, the combination of BP plus TMS caused a slowing of BP biotransformation, with an increase in CYP1A1 and CYP1B1 expression and EROD activity, and a slowing, but no change in magnitude of BPdG formation. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens