Pub. Date : 2011 Sep
PMID : 21669939
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
2 | The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
3 | The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
4 | Therefore, during 96 h of exposure in MCF-7 cells, the combination of BP plus TMS caused a slowing of BP biotransformation, with an increase in CYP1A1 and CYP1B1 expression and EROD activity, and a slowing, but no change in magnitude of BPdG formation. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |