| 1 |
34982085 | Integrated proteomic and metabolomic analyses of the mitochondrial neurodegenerative disease MELAS. | 2022 Mar 28 |
2 |
| 2 |
35433176 | Clinical, laboratory data and outcomes of 17 Iranian citrullinemia type 1 patients: Identification of five novel ASS1 gene mutations. | 2022 May |
1 |
| 3 |
35477090 | FXR/ASS1 axis attenuates the TAA-induced liver injury through arginine metabolism. | 2022 Jun 30 |
4 |
| 4 |
33423701 | Human recombinant arginase I [HuArgI (Co)-PEG5000]-induced arginine depletion inhibits ovarian cancer cell adhesion and migration through autophagy-mediated inhibition of RhoA. | 2021 Jan 11 |
1 |
| 5 |
33478587 | Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells. | 2021 Jan 21 |
7 |
| 6 |
33508432 | Therapeutic targeting of argininosuccinate synthase 1 (ASS1)-deficient pulmonary fibrosis. | 2021 Apr 7 |
2 |
| 7 |
33664852 | Genome-wide CRISPR/Cas9 knockout screening uncovers a novel inflammatory pathway critical for resistance to arginine-deprivation therapy. | 2021 |
2 |
| 8 |
33838671 | Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma. | 2021 Apr 10 |
1 |
| 9 |
33979616 | Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation. | 2021 May 11 |
4 |
| 10 |
34184805 | Snail enhances arginine synthesis by inhibiting ubiquitination-mediated degradation of ASS1. | 2021 Aug 4 |
2 |
| 11 |
34298755 | Arginine Signaling and Cancer Metabolism. | 2021 Jul 15 |
4 |
| 12 |
34344457 | The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer. | 2021 Aug 3 |
1 |
| 13 |
32573723 | Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity. | 2020 Sep 3 |
2 |
| 14 |
32859536 | Phase II Study of Arginine Deprivation Therapy With Pegargiminase in Patients With Relapsed Sensitive or Refractory Small-cell Lung Cancer. | 2020 Nov |
2 |
| 15 |
33051382 | MicroRNA-1291-5p Sensitizes Pancreatic Carcinoma Cells to Arginine Deprivation and Chemotherapy through the Regulation of Arginolysis and Glycolysis. | 2020 Dec |
2 |
| 16 |
33395072 | Arginine metabolism: a potential target in pancreatic cancer therapy. | 2020 Nov 4 |
5 |
| 17 |
30605863 | Metabolic pathways of L-arginine and therapeutic consequences in tumors. | 2019 Mar |
1 |
| 18 |
30796035 | A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma. | 2019 May 1 |
1 |
| 19 |
30808864 | Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma. | 2019 Feb 26 |
1 |
| 20 |
31113844 | Arginine Starvation and Docetaxel Induce c-Myc-Driven hENT1 Surface Expression to Overcome Gemcitabine Resistance in ASS1-Negative Tumors. | 2019 Aug 15 |
2 |
| 21 |
31395686 | Exploiting Arginine Auxotrophy with Pegylated Arginine Deiminase (ADI-PEG20) to Sensitize Pancreatic Cancer to Radiotherapy via Metabolic Dysregulation. | 2019 Dec |
2 |
| 22 |
31795337 | Human Recombinant Arginase I [HuArgI (Co)-PEG5000]-Induced Arginine Depletion Inhibits Colorectal Cancer Cell Migration and Invasion. | 2019 Nov 29 |
1 |
| 23 |
29401583 | Argininosuccinate synthetase 1 contributes to gastric cancer invasion and progression by modulating autophagy. | 2018 May |
2 |
| 24 |
29422017 | Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM. | 2018 Feb 8 |
3 |
| 25 |
29453600 | Argininosuccinate Synthetase-1 (ASS1) Loss in High-Grade Neuroendocrine Carcinomas of the Urinary Bladder: Implications for Targeted Therapy with ADI-PEG 20. | 2018 Sep |
4 |
| 26 |
29597093 | Arginine: Challenges and opportunities of this two-faced molecule in cancer therapy. | 2018 Jun |
2 |
| 27 |
29721066 | Amino Acid Uptake Measured by [18F]AFETP Increases in Response to Arginine Starvation in ASS1-Deficient Sarcomas. | 2018 |
3 |
| 28 |
30108309 | Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes. | 2018 Aug 14 |
5 |
| 29 |
30280600 | Arginine reprogramming in ADPKD results in arginine-dependent cystogenesis. | 2018 Dec 1 |
1 |
| 30 |
30393775 | Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction. | 2018 |
4 |
| 31 |
30466103 | Arginine-Depleting Enzymes - An Increasingly Recognized Treatment Strategy for Therapy-Refractory Malignancies. | 2018 |
1 |
| 32 |
30546006 | Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM. | 2018 Dec 13 |
1 |
| 33 |
26902604 | L-Canavanine Potentiates Cytotoxicity of Chemotherapeutic Drugs in Human Breast Cancer Cells. | 2017 |
2 |
| 34 |
27584578 | Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial. | 2017 Jan 1 |
2 |
| 35 |
27913198 | Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy. | 2017 Mar 1 |
13 |
| 36 |
27979310 | Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase-Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase. | 2017 Jan |
6 |
| 37 |
28187218 | Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma. | 2017 |
2 |
| 38 |
28358054 | Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer. | 2017 Mar 30 |
6 |
| 39 |
28388291 | Phase 1 Dose-Escalation Study of Pegylated Arginine Deiminase, Cisplatin, and Pemetrexed in Patients With Argininosuccinate Synthetase 1-Deficient Thoracic Cancers. | 2017 Jun 1 |
2 |
| 40 |
28587924 | PRMT7 Interacts with ASS1 and Citrullinemia Mutations Disrupt the Interaction. | 2017 Jul 21 |
1 |
| 41 |
28646562 | Argininosuccinate synthase 1 (ASS1): A marker of unclassified hepatocellular adenoma and high bleeding risk. | 2017 Dec |
2 |
| 42 |
28791021 | Reconstitution of T Cell Proliferation under Arginine Limitation: Activated Human T Cells Take Up Citrulline via L-Type Amino Acid Transporter 1 and Use It to Regenerate Arginine after Induction of Argininosuccinate Synthase Expression. | 2017 |
1 |
| 43 |
28832976 | A phase 1/1B trial of ADI-PEG 20 plus nab-paclitaxel and gemcitabine in patients with advanced pancreatic adenocarcinoma. | 2017 Dec 1 |
1 |
| 44 |
28883660 | Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression. | 2017 Sep 7 |
10 |
| 45 |
28969007 | Arginine auxotrophic gene signature in paediatric sarcomas and brain tumours provides a viable target for arginine depletion therapies. | 2017 Sep 8 |
1 |
| 46 |
28985504 | CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. | 2017 Oct 5 |
3 |
| 47 |
29094484 | Degradation of AMPK-α1 sensitizes BRAF inhibitor-resistant melanoma cells to arginine deprivation. | 2017 Dec |
4 |
| 48 |
26096933 | Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents. | 2016 Mar 31 |
6 |
| 49 |
26642391 | Selective Intracellular Delivery of Recombinant Arginine Deiminase (ADI) Using pH-Sensitive Cell Penetrating Peptides To Overcome ADI Resistance in Hypoxic Breast Cancer Cells. | 2016 Jan 4 |
2 |
| 50 |
26771234 | BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanoma. | 2016 Apr 5 |
4 |