Pub. Date : 2021 Jan 21
PMID : 33478587
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells. | Arginine | argininosuccinate synthase 1 | Homo sapiens |
| 2 | Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells. | Arginine | argininosuccinate synthase 1 | Homo sapiens |
| 3 | BACKGROUND: Many cancers silence the metabolic enzyme argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis within the urea cycle. | Arginine | argininosuccinate synthase 1 | Homo sapiens |
| 4 | BACKGROUND: Many cancers silence the metabolic enzyme argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis within the urea cycle. | Arginine | argininosuccinate synthase 1 | Homo sapiens |
| 5 | Consequently, ASS1-negative cells are susceptible to depletion of extracellular arginine by PEGylated arginine deiminase (ADI-PEG20), an agent currently being developed in clinical trials. | Arginine | argininosuccinate synthase 1 | Homo sapiens |
| 6 | As the primary mechanism of resistance to arginine depletion is re-expression of ASS1, we sought a tool to understand the temporal emergence of the resistance phenotype at the single-cell level. | Arginine | argininosuccinate synthase 1 | Homo sapiens |
| 7 | RESULTS: Every ASS1-deficient cell analyzed was found to respond to arginine deprivation by decreased expression of the sensor, indicating an absence of resistance in the naive cell population. | Arginine | argininosuccinate synthase 1 | Homo sapiens |