Title : Arginine reprogramming in ADPKD results in arginine-dependent cystogenesis.

Pub. Date : 2018 Dec 1

PMID : 30280600






1 Functional Relationships(s)
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1 We now show that, in a remarkable parallel to RCC, ASS1 expression is reduced in murine and human ADPKD, and arginine depletion results in a dose-dependent compensatory increase in ASS1 levels as well as decreased cystogenesis in vitro and ex vivo with minimal toxicity to normal cells. Arginine argininosuccinate synthase 1 Homo sapiens