Levodopa

catechol-O-methyltransferase ; Homo sapiens







290 Article(s)
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251 8615170 Effects of catechol-O-methyltransferase (COMT) inhibition on the pharmacokinetics of L-DOPA. 1996 2
252 8726541 Effect of one month's treatment with peripherally acting catechol-O-methyltransferase inhibitor, entacapone, on pharmacokinetics and motor response to levodopa in advanced parkinsonian patients. 1996 Jun 2
253 8807664 Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. 1996 Jun 2
254 8836986 The metabolism of L-DOPA and L-threo-3,4-dihydroxyphenylserine and their effects on monoamines in the human brain: analysis of the intraventricular fluid from parkinsonian patients. 1996 Jul 2
255 8941353 No association between Parkinson's disease and low-activity alleles of catechol O-methyltransferase. 1996 Nov 21 1
256 7651456 Effects of tolcapone in Parkinson's patients taking L-dihydroxyphenylalanine/carbidopa and selegiline. 1995 May 1
257 8527287 Pharmacokinetic-pharmacodynamic interaction between the COMT inhibitor tolcapone and single-dose levodopa. 1995 Sep 1
258 8635184 Acute administration of levodopa-benserazide and tolcapone, a COMT inhibitor, Parkinson's disease. 1995 Jun 2
259 8665534 Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers. 1995 Feb 1
260 8665546 Acute effects of COMT inhibition on L-DOPA pharmacokinetics in patients treated with carbidopa and selegiline. 1995 Aug 2
261 8787797 Pharmacokinetic model of oral levodopa and role of carbidopa in parkinsonian patients. 1995 Dec 1
262 7834959 [The effect of droxidopa on the monoamine metabolsim in the human brain]. 1994 Oct 2
263 7952244 New medical and surgical treatments for Parkinson's disease. 1994 Aug 2
264 8035323 Ethnic differences in erythrocyte catechol-O-methyltransferase activity in black and white Americans. 1994 Jul 2
265 8070503 Low catechol-O-methyltransferase activity in a Saami population. 1994 1
266 8126502 Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease. 1994 Feb 4
267 8127373 Crystal structure of catechol O-methyltransferase. 1994 Mar 24 1
268 8190296 Effect of peripheral catechol-O-methyltransferase inhibition on the pharmacokinetics and pharmacodynamics of levodopa in parkinsonian patients. 1994 May 5
269 27520516 Clinical Potential of Catechol-OMethyltransferase (COMT) Inhibitors as Adjuvants in Parkinson's Disease. 1994 Mar 2
270 8112370 Effect of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease. 1993 1
271 8255478 Catechol-O-methyltransferase inhibitor tolcapone prolongs levodopa/carbidopa action in parkinsonian patients. 1993 Dec 1
272 8341294 Administration of the new COMT inhibitor OR-611 increases striatal uptake of fluorodopa. 1993 Jul 2
273 8477410 The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers. 1993 Apr 3
274 1584187 Treatment strategies for extension of levodopa effect. 1992 May 1
275 1734304 [18F]-6-fluorodopa PET scanning in Parkinson's disease after selective COMT inhibition with nitecapone (OR-462). 1992 Jan 1
276 1875781 Catechol-O-methyltransferase and aromatic L-amino acid decarboxylase activities in human gastrointestinal tissues. 1991 3
277 1884738 Inhibition of human erythrocyte and gastroduodenal catechol-O-methyltransferase activity by nitecapone. 1991 1
278 1958292 (-)-Deprenyl treatment of patients with Parkinson's disease does not affect erythrocyte catechol-O-methyl transferase activity. 1991 3
279 2272023 Effect of a novel catechol-O-methyltransferase inhibitor, nitecapone, on the metabolism of L-dopa in healthy volunteers. 1990 Oct 2
280 2289048 L-dopa as substrate for human duodenal catechol-O-methyltransferase and aromatic L-amino acid decarboxylase. 1990 Nov 1
281 6437857 The pharmacology of Parkinson's disease: basic aspects and recent advances. 1984 Nov 15 1
282 6714437 Human pharmacogenetics of methyl conjugation. 1984 May 15 1
283 6734032 Difference in erythrocyte catechol-O-methyltransferase activity between Orientals and Caucasians: difference in levodopa tolerance. 1984 Jun 2
284 7121609 Catechol-O-methyltransferase inhibition by U-0521 increases striatal utilization of levodopa. 1982 Jul 1
285 7137962 3-O-methyldopa blocks dopa metabolism in rat corpus striatum. 1982 Sep 1
286 7296879 Determination of free and conjugated catecholamines and L-3,4-dihydroxyphenylalanine in plasma and urine: evidence for a catechol-O-methyltransferase inhibitor in uraemia. 1981 Sep 1
287 7398195 Catechol-O-methyltransferase activity: a determinant of levodopa response. 1980 Aug 5
288 847319 [Abnormal movements of patients with Parkinsonism treated with L-dopa and anomalies of dopamine metabolism]. 1977 Jan 1
289 5016575 Metabolism of L-dopa after inhibition of catechol-O-methyl transferase. 1972 Jan 1
290 5112212 Potentiation of the L-Dopa effect in man by the use of catechol-O-methyltransferase inhibitors. 1971 Oct 1