Title : Effect of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease.

Pub. Date : 1993

PMID : 8112370






1 Functional Relationships(s)
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1 A small decrease in the AUC of homovanillic acid (HVA), the COMT dependent metabolite of levodopa, was observed (from 455 to 303 h.ng.ml-1). Levodopa catechol-O-methyltransferase Homo sapiens