Title : Effect of one month's treatment with peripherally acting catechol-O-methyltransferase inhibitor, entacapone, on pharmacokinetics and motor response to levodopa in advanced parkinsonian patients.

Pub. Date : 1996 Jun

PMID : 8726541






2 Functional Relationships(s)
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1 Effect of one month"s treatment with peripherally acting catechol-O-methyltransferase inhibitor, entacapone, on pharmacokinetics and motor response to levodopa in advanced parkinsonian patients. Levodopa catechol-O-methyltransferase Homo sapiens
2 Peripheral COMT inhibition with entacapone increased significantly the bioavailability of levodopa and prolonged its antiparkinsonian effect after a single dose and after repeated dosing for 4 weeks. Levodopa catechol-O-methyltransferase Homo sapiens