Acetaminophen

cytochrome P450, family 1, subfamily a, polypeptide 2 ; Mus musculus







20 Article(s)
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Title
Pub. Year
#Total Relationships
1 32932016 Aryl Hydrocarbon Receptor Activity in Hepatocytes Sensitizes to Hyperacute Acetaminophen-Induced Hepatotoxicity in Mice. 2021 1
2 32946962 Orostachys japonicus ameliorates acetaminophen-induced acute liver injury in mice. 2021 Jan 30 1
3 32360799 Oroxyloside ameliorates acetaminophen-induced hepatotoxicity by inhibiting JNK related apoptosis and necroptosis. 2020 Aug 10 1
4 30030101 Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro. 2018 Oct 1
5 28832650 Fructose diet alleviates acetaminophen-induced hepatotoxicity in mice. 2017 2
6 28963035 miRNA-122 Protects Mice and Human Hepatocytes from Acetaminophen Toxicity by Regulating Cytochrome P450 Family 1 Subfamily A Member 2 and Family 2 Subfamily E Member 1 Expression. 2017 Dec 2
7 29184146 2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2. 2017 Nov 28 2
8 25753323 Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation. 2015 Apr 25 1
9 22291093 IRE1α activation protects mice against acetaminophen-induced hepatotoxicity. 2012 Feb 13 3
10 16611625 Acetaminophen metabolism does not contribute to gender difference in its hepatotoxicity in mouse. 2006 Jul 1
11 14978233 Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver. 2004 Mar 1
12 11323178 The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis. 2001 Mar 31 1
13 10977129 Acetaminophen produces cataract in DBA2 mice by Ah receptor-independent induction of CYP1A2. 2000 Aug 4
14 9633991 Alcohol-mediated increases in acetaminophen hepatotoxicity: role of CYP2E and CYP3A. 1998 May 15 1
15 9772215 Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice. 1998 Sep 2
16 9875304 Role of CYP1A2 in the hepatotoxicity of acetaminophen: investigations using Cyp1a2 null mice. 1998 Nov 2
17 9295056 Increased basal expression of hepatic Cyp1a1 and Cyp1a2 genes in inbred mice selected for susceptibility to acetaminophen-induced hepatotoxicity. 1997 Aug 3
18 8643688 Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism. 1996 Feb 20 1
19 7479582 Cytochrome P4502E1 inhibition by propylene glycol prevents acetaminophen (paracetamol) hepatotoxicity in mice without cytochrome P4501A2 inhibition. 1995 Jun 1
20 8074700 Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity. 1994 Aug 30 4