Pub. Date : 1994 Aug 30
PMID : 8074700
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity. | Acetaminophen | cytochrome P450, family 1, subfamily a, polypeptide 2 | Mus musculus |
| 2 | In non-induced mice, 150 mg/kg APAP caused minimal hepatotoxicity and loss of CYP2E1- but not CYP1A2-dependent activity. | Acetaminophen | cytochrome P450, family 1, subfamily a, polypeptide 2 | Mus musculus |
| 3 | In contrast, 400 mg/kg APAP was hepatotoxic and diminished both CYP2E1 and CYP1A2 activities. | Acetaminophen | cytochrome P450, family 1, subfamily a, polypeptide 2 | Mus musculus |
| 4 | In beta-napthaflavone-pretreated mice, CYP1A2 activity was decreased only by the high dose of APAP, and covalent binding was > 2-fold higher at the high APAP dose. | Acetaminophen | cytochrome P450, family 1, subfamily a, polypeptide 2 | Mus musculus |