| 1 |
34304710 | Regulation of Leukaemia Associated Rho GEF (LARG/ARHGEF12). | 2021 Jul 25 |
2 |
| 2 |
34877508 | GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity. | 2021 Dec 17 |
1 |
| 3 |
29432733 | DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation. | 2018 Feb 26 |
2 |
| 4 |
29695506 | A structural study of the complex between neuroepithelial cell transforming gene 1 (Net1) and RhoA reveals a potential anticancer drug hot spot. | 2018 Jun 8 |
2 |
| 5 |
28318223 | High-Throughput Dual Screening Method for Ras Activities and Inhibitors. | 2017 Apr 18 |
3 |
| 6 |
29036434 | Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation. | 2017 Nov 16 |
2 |
| 7 |
25800835 | Kinetic activation of Rab8 guanine nucleotide exchange factor Rabin8 by Rab11. | 2015 |
1 |
| 8 |
26438819 | p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase. | 2015 Nov 27 |
2 |
| 9 |
24597981 | Amplification of B cell receptor-Erk signaling by Rasgrf-1 overexpression in chronic lymphocytic leukemia. | 2014 Dec |
2 |
| 10 |
24993829 | Structural insights into the activation of the RhoA GTPase by the lymphoid blast crisis (Lbc) oncoprotein. | 2014 Aug 22 |
1 |
| 11 |
25486352 | A new function and complexity for protein translation initiation factor eIF2B. | 2014 |
2 |
| 12 |
22960035 | Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on Ras. | 2013 Jan |
1 |
| 13 |
23422181 | Up-regulation of T-lymphoma and metastasis gene 1 in gastric cancer and its involvement in cell invasion and migration. | 2013 Feb |
2 |
| 14 |
23718289 | Prenylation and membrane localization of Cdc42 are essential for activation by DOCK7. | 2013 Jun 25 |
1 |
| 15 |
25332840 | Quantitative Analysis of Guanine Nucleotide Exchange Factors (GEFs) as Enzymes. | 2013 |
1 |
| 16 |
22448228 | The adaptor molecule Nck localizes the WAVE complex to promote actin polymerization during CEACAM3-mediated phagocytosis of bacteria. | 2012 |
2 |
| 17 |
22752028 | RasGRF1 regulates proliferation and metastatic behavior of human alveolar rhabdomyosarcomas. | 2012 Sep |
1 |
| 18 |
22992742 | Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration. | 2012 Nov 2 |
2 |
| 19 |
23048039 | Spatiotemporal regulation of the ubiquitinated cargo-binding activity of Rabex-5 in the endocytic pathway. | 2012 Nov 23 |
1 |
| 20 |
20949621 | Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. | 2011 Jan |
1 |
| 21 |
21111786 | The RasGrf family of mammalian guanine nucleotide exchange factors. | 2011 Apr |
1 |
| 22 |
21467038 | Ric-8B is a GTP-dependent G protein alphas guanine nucleotide exchange factor. | 2011 Jun 3 |
1 |
| 23 |
22075848 | Prognostic significance of Tiam1 expression in papillary thyroid carcinoma. | 2011 Dec |
2 |
| 24 |
22106281 | Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2. | 2011 Dec 6 |
2 |
| 25 |
20363736 | Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence. | 2010 May 28 |
1 |
| 26 |
21204011 | Crystal structure of the C-terminal domain of the ɛ subunit of human translation initiation factor eIF2B. | 2010 Jun |
2 |
| 27 |
19642867 | Specific induction of migration and invasion of pancreatic carcinoma cells by RhoC, which differs from RhoA in its localisation and activity. | 2009 Oct |
2 |
| 28 |
19692568 | Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors. | 2009 Oct |
2 |
| 29 |
17075039 | A Ras-induced conformational switch in the Ras activator Son of sevenless. | 2006 Nov 7 |
2 |
| 30 |
15557278 | Activation of the phagocyte NADPH oxidase by Rac Guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase. | 2005 Feb 4 |
4 |
| 31 |
15709769 | Mechanism of the guanine nucleotide exchange reaction of Ras GTPase--evidence for a GTP/GDP displacement model. | 2005 Feb 22 |
1 |
| 32 |
15306850 | Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix. | 2004 Sep 1 |
1 |
| 33 |
11336674 | Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1). | 2001 Apr 20 |
2 |
| 34 |
11584276 | Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP. | 2001 Oct |
1 |
| 35 |
10835426 | CalDAG-GEFIII activation of Ras, R-ras, and Rap1. | 2000 Aug 18 |
1 |
| 36 |
10882715 | Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1. | 2000 Sep 22 |
1 |
| 37 |
10089422 | Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation. | 1999 Jan |
2 |
| 38 |
10220378 | G protein beta gamma subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm). | 1999 Apr 27 |
2 |
| 39 |
10369786 | Model of the ran-RCC1 interaction using biochemical and docking experiments. | 1999 Jun 18 |
2 |
| 40 |
10373510 | Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. | 1999 Jul |
3 |
| 41 |
10518015 | Association of the proto-oncogene product dbl with G protein betagamma subunits. | 1999 Oct 8 |
2 |
| 42 |
10608844 | RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans. | 1999 Dec 31 |
4 |
| 43 |
9447979 | GTP hydrolysis is not important for Ypt1 GTPase function in vesicular transport. | 1998 Feb |
1 |
| 44 |
9699463 | GEF-mediated GDP/GTP exchange by monomeric GTPases: a regulatory role for Mg2+? | 1998 Jun |
5 |
| 45 |
9030518 | Residues of the Rho family GTPases Rho and Cdc42 that specify sensitivity to Dbl-like guanine nucleotide exchange factors. | 1997 Feb 21 |
2 |
| 46 |
9312123 | A new function of p120-GTPase-activating protein. Prevention of the guanine nucleotide exchange factor-stimulated nucleotide exchange on the active form of Ha-ras p21. | 1997 Oct 3 |
1 |
| 47 |
8605211 | Investigation of the GTP-binding/GTPase cycle of Cdc42Hs using extrinsic reporter group fluorescence. | 1996 Apr 9 |
2 |
| 48 |
8724692 | Vav: function and regulation in hematopoietic cell signaling. | 1996 May |
2 |
| 49 |
8479540 | The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. | 1993 May 6 |
2 |
| 50 |
2491852 | Mechanism of the nucleotide exchange reaction in eukaryotic polypeptide chain initiation. Characterization of the guanine nucleotide exchange factor as a GTP-binding protein. | 1989 Jan 5 |
9 |