Title : Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.

Pub. Date : 2011 Jan

PMID : 20949621






1 Functional Relationships(s)
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Protein Name
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1 Investigated functional alterations comprise the enhancement of intrinsic and guanine nucleotide exchange factor (GEF) catalyzed nucleotide exchange, which is alternatively accompanied by an impaired GTPase-activating protein (GAP) stimulated GTP hydrolysis, an overall loss of functional properties, and a deficiency in effector interaction. Guanosine Triphosphate Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens